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Centenarians with high vitamin D were 2.9X more likely to be functionally independent – Oct 2018

Prevalence of functional dependence in Chinese centenarians and its relationship with serum vitamin D status

Clinical Interventions in Aging Vol 2018:13 pg 2045—2053; https://doi.org/10.2147/CIA.S182318
Yao Yao,1,* Shihui Fu,2,* Qiuling Shi,3 Hao Zhang,4 Qiao Zhu,5 Fu Zhang,5 Fuxin Luan,5 Yali Zhao,5 Yao He1
1Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China; 3Department of Symptom Research, MD Anderson Cancer Center, Houston, TX, USA; 4Department of Health Policy and Management, Texas A&M University, College Station, TX, USA; 5Central Laboratory, Hainan Branch of Chinese PLA General Hospital, Sanya, People’s Republic of China *These authors contributed equally to this work


10 reasons why seniors need more vitamin D has the following

  1. Senior skin produces 3X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptors as they age
  3. Seniors are indoors more than than when they were younger
    • not as agile, weaker muscles; frail, no longer enjoy hot temperatures
    • (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
  4. Seniors wear more clothing outdoors than when younger
    • Seniors also are told to fear skin cancer/wrinkles
  5. Seniors often take various drugs which reduce vitamin D
  6. Seniors often have one or more diseases which consume vitamin D
  7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
  8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  9. Reduced stomach acid ==>less Magnesium needed to utilize vitamin D
    (would not show up on vitamin D test)
  10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
  11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

 Download the PDF from VitaminDWiki




Background: Functional dependence (FD) and vitamin D deficiency are common conditions in older adults. However, little is known about the relationship between FD and serum vitamin D status in centenarians. The current study was designed to evaluate the prevalence of FD and examine its relationship with serum vitamin D status among centenarians in China.

Subjects and methods: A cross-sectional study of a large sample of Chinese centenarians including 180 men and 822 women was conducted from June 2014 to December 2016. Home interviews, physical examinations, and blood analyses were performed in 958 centenarians following standard procedures. FD was evaluated using the Barthel index of activities of daily living (ADL). Serum 25-hydroxyvitamin D (25OHD) concentrations were measured as a marker of vitamin D status.

Results: The prevalence of centenarians with FD was 71.2%. Vitamin D deficiency, lack of tea consumption, lack of outdoor activities, visual impairment, and fracture were predictors of FD. Centenarians in the lowest quartile of serum 25OHD concentration had an approximately threefold greater likelihood of FD than those in the highest quartile in multiple logistic regression models (OR =2.88; 95% CI 1.75–4.73; P<0.001). The multivariable OR with a 1 ng/mL decrease in serum 25OHD concentration was 1.06 (95% CI 1.04–1.08; P<0.001) for FD.

Conclusion: Serum 25OHD levels have important associations with FD in Chinese centenarians. Future research could focus on the value of intervening in the case of low serum 25OHD levels through vitamin D supplementation and improving ADL in the older population.

Created by admin. Last Modification: Thursday December 27, 2018 11:56:38 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
11105 FD T S2.jpg admin 27 Dec, 2018 11:54 116.06 Kb 361
11104 FD T3.jpg admin 27 Dec, 2018 11:53 80.96 Kb 386
10720 Chinese 100.jpg admin 20 Oct, 2018 15:45 131.49 Kb 420
10719 Chinese centenarians.pdf admin 20 Oct, 2018 15:28 607.26 Kb 401
10716 Significant FD.jpg admin 20 Oct, 2018 15:27 22.91 Kb 202
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