Prevalence of functional dependence in Chinese centenarians and its relationship with serum vitamin D status
Clinical Interventions in Aging Vol 2018:13 pg 2045—2053; https://doi.org/10.2147/CIA.S182318
Yao Yao,1,* Shihui Fu,2,* Qiuling Shi,3 Hao Zhang,4 Qiao Zhu,5 Fu Zhang,5 Fuxin Luan,5 Yali Zhao,5 Yao He1
1Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China; 3Department of Symptom Research, MD Anderson Cancer Center, Houston, TX, USA; 4Department of Health Policy and Management, Texas A&M University, College Station, TX, USA; 5Central Laboratory, Hainan Branch of Chinese PLA General Hospital, Sanya, People’s Republic of China *These authors contributed equally to this work
- Frailty risk increases 12 percent for every 10 ng less vitamin D – meta-analysis Sept 2018
- Centenarians with good vitamin D were 1.5 X less likely to depressed – Aug 2018
- Stop Treating 70- and 90-Year-Olds the Same – Aug 2017
- Centenarians have good Vitamin D Receptor genes (or take lots of vitamin D) – March 2016
- Off topic – Caregiving of seniors at home – helpful hints
- Father-in-law of the founder of VitaminDWiki was a centenarian who had lots of vitamin D, etc.
10 reasons why seniors need more vitamin D has the following
- Senior skin produces 3X less Vitamin D for the same sun intensity
- Seniors have fewer vitamin D receptors as they age
(The effect of low Vitamin D receptor genes does not show up on vitamin D test results)
- Seniors are indoors more than when when they were younger
not as agile, weaker muscles; frail, no longer enjoy hot temperatures
(if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
- Seniors wear more clothing outdoors than when younger
fear skin cancer/wrinkles, sometimes avoid bright light after cataract surgery
- Seniors often take various drugs which reduce vitamin D (some would not show up on vitamin D test) statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
- Seniors often have one or more diseases which consume vitamin D ( osteoporosis, diabetes, MS, ...)
- Seniors generally put on weight at they age - and a heavier body requires more vitamin D
- Seniors often (40%) have fatty livers – which do not process vitamin D as well
- Seniors not have as much Magnesium needed to use vitamin D
(would not show up on vitamin D test)
- Seniors with poorly functioning kidneys do not process vitamin D as well
(would not show up on vitamin D test) 2009 full text online Also PDF 2009
- Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)
- Category Seniors and Vitamin D
Background: Functional dependence (FD) and vitamin D deficiency are common conditions in older adults. However, little is known about the relationship between FD and serum vitamin D status in centenarians. The current study was designed to evaluate the prevalence of FD and examine its relationship with serum vitamin D status among centenarians in China.
Subjects and methods: A cross-sectional study of a large sample of Chinese centenarians including 180 men and 822 women was conducted from June 2014 to December 2016. Home interviews, physical examinations, and blood analyses were performed in 958 centenarians following standard procedures. FD was evaluated using the Barthel index of activities of daily living (ADL). Serum 25-hydroxyvitamin D (25OHD) concentrations were measured as a marker of vitamin D status.
Results: The prevalence of centenarians with FD was 71.2%. Vitamin D deficiency, lack of tea consumption, lack of outdoor activities, visual impairment, and fracture were predictors of FD. Centenarians in the lowest quartile of serum 25OHD concentration had an approximately threefold greater likelihood of FD than those in the highest quartile in multiple logistic regression models (OR =2.88; 95% CI 1.75–4.73; P<0.001). The multivariable OR with a 1 ng/mL decrease in serum 25OHD concentration was 1.06 (95% CI 1.04–1.08; P<0.001) for FD.
Conclusion: Serum 25OHD levels have important associations with FD in Chinese centenarians. Future research could focus on the value of intervening in the case of low serum 25OHD levels through vitamin D supplementation and improving ADL in the older population.
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