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Young white children helped by 1500 IU of vitamin D – Jan 2019

Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study).

Ital J Pediatr. 2019 Jan 28;45(1):18. doi: 10.1186/s13052-018-0590-x.

VitaminDWiki

1500 IU is not enough for children who are:

  1. Older (have larger bodies)
  2. Dark Skinned
  3. Overweight
  4. Indoors much of the time

Latitude of 45 degrees = North Italy = Minneapolis, Minn.
Infant-Child category starts with

Having a good level of vitamin D cuts in half the amount of:

Need even more IUs of vitamin D to get a good level if;

  • Have little vitamin D: premie, twin, mother did not get much sun access
  • Get little vitamin D: dark skin, little access to sun
  • Vitamin D is consumed faster than normal due to sickness
  • Older (need at least 100 IU/kilogram, far more if obese)
  • Not get any vitamin D from formula (breast fed) or (fortified) milk
    Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

 Download the PDF from VitaminDWiki
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Mazzoleni S1, Magni G2,3, Toderini D4.
1 Primary Care Paediatrician Azienda ULSS 6 Euganea Regione Veneto, Polistudio Pediatrico, via D'Annunzio 3/A, Piove di Sacco, Padova, Italy. stefano.mazzoleni at aulss6.veneto.it.
2 Senior Biostatistician, NRC Azienda Ospedaliera Padova, Padova, Italy.
3 Unità di Ricerca Clinica, Istituto Oncologico Veneto, Padova, Italy.
4 Endocrinologist and General Practitioner Azienda ULSS 6 Euganea Regione Veneto, Studio via Benizzi 6, Padova, Italy.

BACKGROUND:
The appropriate dose of vitamin D supplementation in children is still debated. We calculated that the recommended dose of 600-1000 IU vitamin D3/day is not sufficient to reach a serum 25-hydroxyvitamin D (25-OH-D) level of at least 30 ng/ml (75 nmol/l) in north Italian children > 12 months. The aim of this study was to analyse the effect of seasonal supplementation with 1500 IU (=37.5 μg) vitamin D3/day.

METHODS:
DINOS (D-vitamIN Oral Supplementation) study was a pilot, monocentric, non-random case-control register study. It was conducted in a paediatric primary care setting near Padova (North Italy, 45°N latitude). The data of 203 children (girls:boys 1:1,33) aged 2-15 years, collected between November 2010 and January 2015, were analysed. Active group A (n = 82) were given 1500 IU vitamin D3/day from November to April; control Group B (n = 121) received no supplementation. The serum 25-OH-D test was part of a laboratory tests panel and performed using a chemiluminescence immunoassay method.

RESULTS:
Serum 25-OH-D mean level + standard deviation throughout the period was 32 + 13 ng/ml (80 + 32 nmol/l) in group A vs 22 + 10 ng/ml (55 + 25 nmol/l) in group B. In group A 12% had vitamin D deficiency 25-OH-D < 20 ng/ml (50 nmol/l) and 1.2% severe vitamin D deficiency 25-OH-D < 10 ng/ml (25 nmol/l). In group B 46% had vitamin D deficiency and 9% severe deficiency (P <  0.001). In group A mean levels were normal or near-normal all the year except in May. Group B reached mean 25-OH-D levels close to 30 ng/ml (75 nmol/l) only in late summer. The active group mean 25-OH-D level was normal in preschoolers and schoolers but not in adolescents. Non-white children had a three-times vitamin D deficiency probability despite supplementation.

CONCLUSIONS:
Vitamin D supplementation with at least 1500 IU vitamin D3/day from November to April was found appropriate for children in North Italy. A prolongation until May could be useful. Higher doses and/or prolonged periods could be more appropriate especially in adolescents and in non-white children.

Attached files

ID Name Comment Uploaded Size Downloads
11298 Age.jpg admin 30 Jan, 2019 28.45 Kb 459
11297 1500 IU F1.jpg admin 30 Jan, 2019 22.81 Kb 476
11296 1500 IU.pdf admin 30 Jan, 2019 1.12 Mb 494