Impact of 25-Hydroxy Vitamin D on White Matter Hyperintensity in Elderly Patients: A Systematic Review and Meta-Analysis
Front Neurol. 2022 Jan 14;12:721427. doi: 10.3389/fneur.2021.721427.
Yilei Zhao 1, Jingfeng Xu 1, Zhan Feng 1, Jincheng Wang 1
Some studies show that low serum vitamin D levels are associated with white matter hyperintensity (WMH), while other studies report no association. This meta-analysis aimed to investigate the presence of an association between serum 25-hydroxy vitamin D [25(OH)D] levels and WMH. PubMed, Embase, the Cochrane Library, CNKI, WANFANG, and VIP were searched for available papers published up to December 2020. The outcomes were the odds ratios (ORs) with 95% confidence intervals (CIs) for the association between different vitamin D statuses and WMH. All meta-analyses were performed using a random-effects model. Five studies (4393 patients) were included. Compared with sufficient 25(OH)D levels, 25(OH)D deficiency was not associated with WMH (OR = 1.67, 95%CI: 0.92-3.04; I2 = 70.2%, P heterogeneity = 0.009), nor was 25(OH)D insufficiency (OR = 1.21, 95%CI: 0.89-1.65; I2 = 48.1%, P heterogeneity = 0.103).
A decrease of 25 nmol/L in 25(OH)D levels was associated with WMH (OR = 1.83, 95%CI: 1.34-2.49; I2 = 0%, P heterogeneity= 0.512). The sensitivity analyses showed that the results were robust. 25(OH)D deficiency and insufficiency are not associated with WMH. A decrease of 25 nmol/L in 25(OH)D levels was associated with WMH, but this result will have to be confirmed. Prospective trials, both cross-sectional and longitudinal, are necessary to examine the association between 25(OH)D levels and WMH.
Download the PDF from VitaminDWiki
VitaminDWiki - related
- Brains of seniors had 60 percent more white matter abnormalities if low vitamin D – March 2015
- Following a stroke, 10 ng less vitamin D associated with 2X more white matter hyperintensities – Nov 2014
- 33 percent more white matter abnormality in brain (periventricular WMA) if low vitamin D – July 2014
- Parkinsons' disease and MRI white matter in brain
- Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014
- Stroke – many MRI measures are strongly associated with low vitamin D – Jan 2015
- Vitamin D remyelinates rats (perhaps remyelinates human MS) – Dec 2019
- Multiple Sclerosis – more gray matter and fewer relapses if 10 ng more vitamin D – Oct 2015
- Multiple Sclerosis WMH disappeared with 150 ng of vitamin d
- Search for "White Matter" 329 results as of Jan 2022