Eur J Endocrinol. 2014 Sep;171(3):R101-10. doi: 10.1530/EJE-14-0158. Epub 2014 May 28.
Muscogiuri G1, Mitri J2, Mathieu C2, Badenhoop K2, Tamer G2, Orio F3, Mezza T2, Vieth R3, Colao A2, Pittas A2.
It has been suggested that vitamin D may play a role in the pathogenesis of several endocrine diseases, such as hyperparathyroidism, type 1 diabetes (T1DM), type 2 diabetes (T2DM), autoimmune thyroid diseases, Addison's disease and polycystic ovary syndrome (PCOS). In this review, we debate the role of vitamin D in the pathogenesis of endocrine diseases.
Narrative overview of the literature synthesizing the current evidence retrieved from searches of computerized databases, hand searches and authoritative texts.
Evidence from basic science supports a role for vitamin D in many endocrine conditions. In humans, inverse relationships have been reported not only between blood 25-hydroxyvitamin D and parathyroid hormone concentrations but also with risk of T1DM, T2DM, and PCOS. There is less evidence for an association with Addison's disease or autoimmune thyroid disease. Vitamin D supplementation may have a role for prevention of T2DM, but the available evidence is not consistent.
Although observational studies support a potential role of vitamin D in endocrine disease, high quality evidence from clinical trials does not exist to establish a place for vitamin D supplementation in optimizing endocrine health. Ongoing randomized controlled trials are expected to provide insights into the efficacy and safety of vitamin D in the management of endocrine disease.
© 2014 European Society of Endocrinology. PMID: 24872497
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- Hyperparathyroidism – still not absolutely, positively sure that vitamin D should be used to treat it – March 2014
- Long term Hashimoto's Thyroiditis has lower level of vitamin D – Jan 2013
- 50,000 IU vitamin D weekly is safe and effective for Primary Hyperparathyroidism – Jan 2013
- Primary Hyperparathyroidism perfectly predicted with a Vitamin D-Based nomogram – Nov 2011
- Fertility problem (PCOS) reduced by vitamin D: many studies
- Women with PCOS 4 X more likely to develop T2 Diabetes (no surprise, both associated with low vitamin D) - Aug 2017
- Overview Thyroid and Vitamin D
- Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
426 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
which are just some of the vitamin D cofactors
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