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Vitamin D helps with T2 Diabetes, hyperparathyroidism, PCOS, and some other endocinological diseases – Sept 2014

Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease.

Eur J Endocrinol. 2014 Sep;171(3):R101-10. doi: 10.1530/EJE-14-0158. Epub 2014 May 28.
Muscogiuri G1, Mitri J2, Mathieu C2, Badenhoop K2, Tamer G2, Orio F3, Mezza T2, Vieth R3, Colao A2, Pittas A2.


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OBJECTIVE:
It has been suggested that vitamin D may play a role in the pathogenesis of several endocrine diseases, such as hyperparathyroidism, type 1 diabetes (T1DM), type 2 diabetes (T2DM), autoimmune thyroid diseases, Addison's disease and polycystic ovary syndrome (PCOS). In this review, we debate the role of vitamin D in the pathogenesis of endocrine diseases.

METHODS:
Narrative overview of the literature synthesizing the current evidence retrieved from searches of computerized databases, hand searches and authoritative texts.

RESULTS:
Evidence from basic science supports a role for vitamin D in many endocrine conditions. In humans, inverse relationships have been reported not only between blood 25-hydroxyvitamin D and parathyroid hormone concentrations but also with risk of T1DM, T2DM, and PCOS. There is less evidence for an association with Addison's disease or autoimmune thyroid disease. Vitamin D supplementation may have a role for prevention of T2DM, but the available evidence is not consistent.

CONCLUSIONS:
Although observational studies support a potential role of vitamin D in endocrine disease, high quality evidence from clinical trials does not exist to establish a place for vitamin D supplementation in optimizing endocrine health. Ongoing randomized controlled trials are expected to provide insights into the efficacy and safety of vitamin D in the management of endocrine disease.

© 2014 European Society of Endocrinology. PMID: 24872497
 Download the PDF from VitaminDWiki.


See also VtiaminDWiki

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 434 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
        which are just some of the vitamin D cofactors

Attached files

ID Name Comment Uploaded Size Downloads
4395 Endocrine Table 1.jpg admin 23 Sep, 2014 13:52 116.62 Kb 3546
4394 endocrine health and disease.pdf PDF 2014 admin 23 Sep, 2014 13:52 155.61 Kb 773
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