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Vitamin D helps with T2 Diabetes, hyperparathyroidism, PCOS, and some other endocinological diseases – Sept 2014

Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease.

Eur J Endocrinol. 2014 Sep;171(3):R101-10. doi: 10.1530/EJE-14-0158. Epub 2014 May 28.
Muscogiuri G1, Mitri J2, Mathieu C2, Badenhoop K2, Tamer G2, Orio F3, Mezza T2, Vieth R3, Colao A2, Pittas A2.


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OBJECTIVE:
It has been suggested that vitamin D may play a role in the pathogenesis of several endocrine diseases, such as hyperparathyroidism, type 1 diabetes (T1DM), type 2 diabetes (T2DM), autoimmune thyroid diseases, Addison's disease and polycystic ovary syndrome (PCOS). In this review, we debate the role of vitamin D in the pathogenesis of endocrine diseases.

METHODS:
Narrative overview of the literature synthesizing the current evidence retrieved from searches of computerized databases, hand searches and authoritative texts.

RESULTS:
Evidence from basic science supports a role for vitamin D in many endocrine conditions. In humans, inverse relationships have been reported not only between blood 25-hydroxyvitamin D and parathyroid hormone concentrations but also with risk of T1DM, T2DM, and PCOS. There is less evidence for an association with Addison's disease or autoimmune thyroid disease. Vitamin D supplementation may have a role for prevention of T2DM, but the available evidence is not consistent.

CONCLUSIONS:
Although observational studies support a potential role of vitamin D in endocrine disease, high quality evidence from clinical trials does not exist to establish a place for vitamin D supplementation in optimizing endocrine health. Ongoing randomized controlled trials are expected to provide insights into the efficacy and safety of vitamin D in the management of endocrine disease.

© 2014 European Society of Endocrinology. PMID: 24872497
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Attached files

ID Name Comment Uploaded Size Downloads
4395 Endocrine Table 1.jpg admin 23 Sep, 2014 116.62 Kb 5633
4394 endocrine health and disease.pdf admin 23 Sep, 2014 155.61 Kb 1527