The Association Between Severity of Vitamin D Deficiency and Hashimoto's Thyroiditis
Journal Endocrine Practice, Online Jan 21 2013, Pages 1-14
Nujen Colak Bozkurt, MD1, Basak Karbek, MD1, Bekir Ucan, MD1, Mustafa Sahin, MD2, Erman Cakal, MD1, Mustafa Ozbek, MD1, Tuncay Delibasi, MD1
1 Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital
2 Department of Endocrinology and Metabolism, Ankara University School of Medicine, Ankara, Turkey
Objective: The relation between vitamin-D and autoimmune disorders has long been investigated regarding to important roles of this hormone in immune regulation.
We evaluated 25-hydroxy-vitamin-D (25OHD) status of subjects with Hashimoto's thyroiditis (HT) and healthy controls.
Methods: Group-1 consisted of 180 euthyroid patients (123 females/57 males) with HT who were on stable dose of L-thyroxine (LT). Sex, age and BMI matched 180 euthyroid subjects with newly diagnosed HT were considered as Group-2 and healthy volunteers (n=180) were enrolled as controls (Group-3). All subjects (n=540) underwent thyroid ultrasound and were evaluated for serum 25OHD, anti-thyroid peroxidase(anti-TPO) and anti-thyroglobulin (anti-TG) levels.
Results: Group-1 had the lowest 25OHD levels (11.4±5.2 ng/mL) compared to newly diagnosed HT subjects (Group-2) (13.1±5.9 ng/mL, p=0.002) and to control subjects (15.4±6.8 ng/mL, p<0.001). Serum 25OHD levels directly correlated to thyroid volume (r=0.145, p<0.001) and inversely correlated to anti-TPO (r=-0.361,p<0.001) and anti-TG levels (r=-0.335,p<0.001). The 48.3% of group-1, 35% of group-2, and 20.5% of controls had severe vitamin-D deficiency (25OHD <10ng/ml). Female chronic HT patients had the lowest serum 25OHD levels (10.3±4.58ng/mL), while male control subjects had the highest (19.3±5.9ng/mL) (p<0.001).
Conclusions: We showed that serum 25OHD levels of patients with HT were significantly lower than controls and severity of vitamin-D deficiency correlated with duration of HT, thyroid volume and antibody levels. These findings may suggest a potential role of 25OHD in development of Hashimoto's thyroiditis and/or its progression to hypothyroidism.
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Summary by VitaminDWiki
| Long term HT | 11 ng, | 48% < 10 ng |
| New HT | 14 ng, | 35% < 10ng |
| Non HT | 15 ng, | 20% < 10ng |
See also VitaminDWiki
- Hashimoto's Thyroiditis and Vitamin D - multiple studies includes 2nd article written in 2014
- Autoimmune disorder patients in Brazil helped by vitamin D – video and Facebook – Nov 2012
Note: Doctors uses LOTS of vitamin D to CURE MS in Brazil, mentions HT