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Vitamin D doubled from 400 to 800 IU in Ireland during pandemic (need 5X more) - Aug 2022


BMJOPEN http://dx.doi.org/10.1136/bmjopen-2021-059477
Malachi J McKenna1 malachi.mckenna at ucd.ie, Oonagh C Lyons2, Mary AT Flynn2, Rachel K Crowley1, Patrick J Twomey1, Mark T Kilbane1

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Objectives Since the onset of the COVID-19 pandemic in 2020, there have been plausible suggestions about the need to augment vitamin D intake by supplementation in order to prevent SARS-CoV2 infection and reduce mortality. Some groups have advocated supplementation for all adults, but governmental agencies have advocated targeted supplementation. We sought to explore the effect of the COVID-19 pandemic on both vitamin D status and on the dose of new-to-market vitamin D supplements.

Setting University hospital, Dublin, Ireland.

Participants Laboratory-based samples of circulating 25-hydroxyvitamin D (25OHD) (n=100 505).

Primary and secondary outcome measures Primary outcomes: comparing yearly average 25OHD prior to the pandemic (April 2019 to March 2020) with during the pandemic (April 2020 to March 2021) and comparing the dose of new-to-market vitamin D supplements between 2017 and 2021 (n=2689). Secondary outcome: comparing prevalence of vitamin D deficiency and vitamin D excess during the two time periods.

Results The average yearly serum 25OHD measurement increased by 2.8 nmol/L (61.4, 95% CI 61.5 to 61.7 vs 58.6, 95% CI 58.4 to 58.9, p<0.001), which was almost threefold higher than two similar trend analyses that we conducted between 1993 and 2016. There was a lower prevalence of low 25OHD and a higher prevalence of high 25OHD. The dose of new-to-market vitamin D supplements was higher in the years 2020–2021 compared with the years 2017–2019 (p<0.001).

Conclusions We showed significant increases in serum 25OHD and in the dose of new-to-market vitamin D supplements. The frequency of low vitamin D status reduced indicating benefit, but the frequency of vitamin D excess increased indicating risk of harm. Rather than a blanket recommendation about vitamin D supplementation for all adults, we recommend a targeted approach of supplementation within current governmental guidelines to at-risk groups and cautioning consumers about adverse effects of high dose supplements on the market.
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Created by admin. Last Modification: Thursday August 4, 2022 18:52:24 GMT-0000 by admin. (Version 8)

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ID Name Comment Uploaded Size Downloads
18246 Doubled.jpg admin 04 Aug, 2022 18:11 31.38 Kb 46
18245 Monthly.jpg admin 04 Aug, 2022 18:10 44.80 Kb 37
18244 COVID Vitamin D dose sizes_CompressPdf.pdf PDF 2022 admin 04 Aug, 2022 18:09 221.63 Kb 9
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