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PICU children with low vitamin D levels have worse health scores (PRISM-III) – Feb 2020

25-Hydroxy Vitamin D Deficiency Is Associated With Cardiovascular Sequential Organ Failure Assessment and Pediatric Risk of Mortality III Scores in Critically Ill Children

Front. Pediatr., 28 February 2020 | https://doi.org/10.3389/fped.2020.00066

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Hongxing Dang1,2,3, Jing Li1,2,3, Chengjun Liu1,2,3 and Feng Xu1,2,3*

  • 1 Department of PICU, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China
  • 2 National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
  • 3 Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China

Aim: Investigate 25-hydroxy vitamin D (25(OH)D) levels and the correlation with cardiovascular sequential organ failure assessment (CV-SOFA) and pediatric risk of mortality III (PRISM-III) scores in critically ill children.

Methods: This prospective observational cohort study was conducted on consecutive critical ill children aged 1 month to 14 years old in 1 year. The blood sample was collected upon PICU admission. 25(OH)D deficiency was defined as<20 ng/mL. We performed univariate and multivariate analyses to evaluate associations with CV-SOFA and PRISM-III scores and other important outcomes.

Results: 296 critically ill children were enrolled in the study. The mean serum 25(OH)D level was 22.5 (IQR 16.3–31.8) ng/mL. The prevalence of 25(OH)D deficiency was 39.2% in critically ill children. 25(OH)D levels were significantly decreased in septic shock and associated with CV-SOFA and PRISM-III scores. In multivariate analysis, vitamin D deficiency is associated with CV—SOFA and PRISM—III scores.

Conclusion: 25(OH)D deficiency is prevalent in critically ill children at PICU admission and seems to be associated with higher CV-SOFA and PRISM-III scores. Our study provides additional data for 25 (OH) D statuses that impact the outcomes of critically ill children.


Created by admin. Last Modification: Friday February 28, 2020 21:46:31 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
13557 PICU table.jpg admin 28 Feb, 2020 18:42 50.22 Kb 87
13556 PRiSM-III scores.jpg admin 28 Feb, 2020 18:42 36.88 Kb 98
13555 Children ICU.pdf PDF 2020 admin 28 Feb, 2020 18:41 1.29 Mb 83
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