Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins
Environmental Advances Volume 17, October 2024, https://doi.org/10.1016/j.envadv.2024.100585
Background
Per-and polyfluoroalkyl substances (PFAS) contamination may disrupt sleep through disrupted metabolic and immune functions. The study aims to investigate the association and potential mechanism between PFAS and sleep.
Methods
We included 136 young adults recruited between 2014-2018 and 76 were re-assessed between 2020-2022. Additional 8 participants only had complete data between 2020-2022. Plasma PFAS (PFOS, PFOA, PFHxS, PFHpS, PFPeS, PFNA, PFDA) were measured at both visits using liquid-chromatography high-resolution mass spectrometry. Plasma proteins were measured by Olink® Explore 384 Cardiometabolic and Inflammation Panel I. Sleep duration was self-reported at both visits along with follow-up sleep disturbance and sleep-related impairment using validated instruments. We utilized multiple linear regression to explore the association between individual PFAS (in tertile) and these sleep outcomes. PFAS associated with sleep outcomes were subjected to computational toxicology analysis using the Comparative Toxicogenomics Database and Toxicology in the 21st Century database to identify potential genetic links between them. Mediation analysis using proteomic data was then performed to confirm the findings from computational toxicology analysis.
Results
At baseline, one tertile increase in
- PFDA was associated with 0.39 (95 % CI: 0.05, 0.73) hours of shorter nightly sleep duration,
- and, at follow-up PFHxS and PFOA were associated with 0.39 (95 % CI: 0.05, 0.72)
- and 0.32 (95 % CI: 0.01, 0.63) hours shorter sleep duration, respectively
- One tertile increase in PFOS exposure was associated with a 2.99-point increase in sleep disturbance scores (95 % CI: 0.67, 5.31)
- and a 3.35-point increase in sleep-related impairment scores (95 % CI: 0.51, 6.20).
Computational toxicology and mediation analyses identified potential mediating roles for several proteins in the PFAS-sleep associations, including 11-beta-dehydrogenase isozyme 1 (HSD11B1), cathepsin B (CTSB) and several immune system-related proteins.
Conclusion
Future large scale epidemiological and mechanistic studies should confirm our findings and test effect measure modification of the associations by age.
Download the PDF from VitaminDWiki
VitaminDWiki – Sleep category contains
A few items in SLEEP category
- Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
- Sleep disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
- Sleep, Dr. Gominak and Vitamin D - several studies
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Vitamin D for better sleep video - Dec 2021
- 5X increase in sleep problems in a decade in US Veterans
- Sleep Apnea and Vitamin D - many studies
- Melatonin and Vitamin D - many studies does much more than improve sleep
VitaminDWiki – PFAS (forever chemicals) reduce Vitamin D and VDR, cause health problems - many studies
VitaminDWiki – Microplastics now causing problems in most life forms - many studies
44,900 hits for sleep (plastics OR PFAS) Oct 2024
- Per- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005–2014 - Nov 2023 https://doi.org/10.1016/j.envres.2023.117092
- Household income modifies associations between prenatal PFAS exposure and sleep problems in early childhood - Aug 2023 FREE PDF
- Is exposure to chemical pollutants associated with sleep outcomes? A systematic review - Aug 2023 FREE PDF
- Sleep matters: Neurodegeneration spectrum heterogeneity, combustion and friction ultrafine particles, industrial nanoparticle pollution, and sleep disorders—Denial is not an option - Feb 2023 FREE PDF
| 71 visitors, last modified 19 Oct, 2024, |