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Off topic: Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc.

DMSO is able to enhance “small sized” molecules (< 500 daltons) getting through the skin
Have not yet found out the DMSO "speedup factor"
DMSO was made in 1860 and its transdermal properties were discovered about 40 years later
High concentration DMSO has used on the skin for various purposed 4 times a day for a month
DMSO by itself has various health benefits
The 500 Dalton Rule of Dermal Penetration and Cosmetic Science March 2017
This 500 dalton size limit was also mentioned in one of the DMSO references below
Here are a few Dalton Sizes

L Ascorbic Acid:176 Daltons
Resveratrol 228 Daltons
Testosterone 288 Daltons
Vitamin D 400 Daltons
Magnesium ion
Chloride
24 Daltons
Water 18 Daltons

Notes by Henry Lahore, founder of VitaminDWiki

I have successfully using low concentration DMSO in an aloe vera gel on my skin to get Magnesium and Boron into my body

In April 2019 I got a painful shoulder which I assumed was Calcium deposits, similar to my wife's which were diagnosed by MRI
I found a reference on the web to the use of an acid (Ascorbic Acid) to disolve Calcium
After just a few days my shoulder pain appears to have gone away

  • Calcium deposits melted by Ascorbic Acid and DMSO – 2010
    He believes that that the slight acidification of the region under the skin disolved the Calcium deposits
    The author describes exactly what he did to get his shoulder pain to go away
    Interesting to note - after a few months his pain came back, and quickly went away after re-application of the mixture

Note: Suspect that my Vitamin K (Super K LEF) did not keep Calcium from accumulating in my soft tissues

Expect to experiment with transdermal Vitamin D and Resveratrol in the future


See also VitaminDWiki


See also web

Permeation enhancer strategies in transdermal drug delivery - July 2014

Describes a wide variety array of ways to get drugs thru the skin
Drug permeability: arm, back, abdomen are much better than the palm
Image
 Download the PDF from VitaminDWiki

Investigating Transdermal Delivery of Vitamin D3 - Aug 2015

 Download the PDF from VitaminDWiki

Enhancement of transdermal drug delivery via synergistic action of chemicals - 2009

Vitamin D penetration enhancement by dodecylamine
Image
 Download the PDF from VitaminDWiki

Dimethyl Sulfoxide - History, Chemistry, and Clinical Utility in Dermatology - Sept 2012

 Download the PDF from VitaminDWiki

Chemical Penetration Enhancers for Transdermal Drug Delivery Systems - April 2009

 Download the PDF from VitaminDWiki

Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs - Sept 2011 10.3810/psm.2011.09.1923

15 Benefits of Methylsulfonylmethane (MSM) - self-hacked

"Methylsulfonylmethane (MSM) is a naturally occurring sulfur compound stored in every cell of the body. It helps the hair, skin, and nails grow faster, softer and stronger apart from improving neurological functions and reducing pain"
MSM was developed after DMSO

Overview at DMSO.ORG

  • "Dimethyl sulfoxide (DMSO), a by-product of the wood industry, has been in use as a commercial solvent since 1953. It is also one of the most studied but least understood pharmaceutical agents of our time- -at least in the United States. According to Stanley Jacob, MD, a former head of the organ transplant program at Oregon Health Sciences University in Portland, more than 40,000 articles on its chemistry have appeared in scientific journals, which, in conjunction with thousands of laboratory studies, provide strong evidence of a wide variety of properties. (See Major Properties Attributed to DMSO) Worldwide, some 11,000 articles have been written on its medical and clinical implications, and in 125 countries throughout the world, including Canada, Great Britain, Germany, and Japan, doctors prescribe it for a variety of ailments, including pain, inflammation, scleroderma, interstitial cystitis, and arthritis elevated intercranial pressure."
  • "In the first flush of enthusiasm over the drug, six pharmaceutical companies embarked on clinical studies. Then, in November 1965, a woman in Ireland died of an allergic reaction after taking DMSO and several other drugs. Although the precise cause of the woman's death was never determined, the press reported it to be DMSO. Two months later, the FDA closed down clinical trials in the United States, citing the woman's death and changes in the lenses of certain laboratory animals that had been given doses of the drug many times higher than would be given humans."
  • "Some 20 years and hundreds of laboratory and human studies later, no other deaths have been reported, nor have changes in the eyes of humans been documented or claimed. Since then, however, the FDA has refused seven applications to conduct clinical studies, and approved only 1, for intersititial cystitis, which subsequently was approved for prescriptive use in 1978."

Reminds me of the Vitamin D scare in the 1950's, which also proved to be totally wrong - Founder of VitaminDWiki
Has the following literature categories

  • Alzheimer's
  • Arthritis
  • Altherosclerosis
  • Chemical Injury & Ischemia
  • Fibromyalgia
  • Herpes
  • Interstitial Cystitis
  • Lupus
  • Malignancy
  • Mental Retardation
  • Nervous System
  • Niemann-Pick Disease
  • Pharmacology
  • Scleroderma
  • Skin and Tissue
  • Stroke
  • Tramatic Brain Injury

Biohack: DMSO for Transdermal Substance Delivery May 2016


Created by admin. Last Modification: Saturday June 22, 2019 17:32:01 GMT-0000 by admin. (Version 15)

Attached files

ID Name Comment Uploaded Size Downloads
11879 Chemical Penetration Enhancers for Transdermal.pdf admin 30 Apr, 2019 21:56 76.92 Kb 317
11878 Vitamin D denetration enhancement.jpg admin 30 Apr, 2019 17:51 30.79 Kb 2006
11877 Drug permeability.jpg admin 30 Apr, 2019 17:51 30.15 Kb 1973
11876 Investigating Transdermal Delivery of Vitamin D3.pdf admin 30 Apr, 2019 17:50 765.04 Kb 409
11875 Permeation enhancer strategies in transdermal drug delivery.pdf admin 30 Apr, 2019 17:50 2.25 Mb 483
11874 transdermal drug delivery.pdf admin 30 Apr, 2019 17:49 286.68 Kb 312
11873 DMSO.pdf admin 30 Apr, 2019 17:49 47.77 Kb 410
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