Neurology. 2017 Jan 3;88(1):44-51. doi: 10.1212/WNL.0000000000003454. Epub 2016 Nov 30.
Nielsen NM1, Munger KL2, Koch-Henriksen N2, Hougaard DM2, Magyari M2, Jørgensen KT2, Lundqvist M2, Simonsen J2, Jess T2, Cohen A2, Stenager E2, Ascherio A2.
Alternately: 10 ng increase in vitamin D level ==> 30% less likely to get MS
Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017
MS prevention by UV is 2X better than prevention by vitamin D levels – Jan 2012
Overview MS and vitamin D
- Multiple Sclerosis 40 percent more likely if mother had low vitamin D – meta-analysis Jan 2020
- High-dose Vitamin D for Multiple Sclerosis is OK while pregnant – Sept 2019
- Extended breastfeeding cut in half the risk of Multiple Sclerosis – July 2017
- Multiple Sclerosis risk reduced 30 percent by each additional 10 ng of vitamin D at birth (1500 Danes) – Jan 2017
- A gestational dose of vitamin D per day keeps the MS doctor away (2X reduction) – Nov 2016
- Multiple Sclerosis 2X more likely if vitamin D deficient as a fetus decades earlier – May 2016
- No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015
- Season of birth associated with pneumonia (10 pcnt) and multiple sclerosis (30 pcnt) – May 2013
- Multiple Sclerosis more likely if mother had less than 25 ng of vitamin D – Nov 2012
- Multiple Sclerosis 23 percent more likely if born in April vs. Oct – meta-analysis Nov 2012
- High vitamin D in moms decreased MS incidence in daughters by 40% – July 2011
As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we aimed to examine the direct association between level of neonatal vitamin D and risk of MS.
We carried out a matched case-control study. Dried blood spots samples (DBSS) belonging to 521 patients with MS were identified in the Danish Newborn Screening Biobank. For every patient with MS, 1-2 controls with the same sex and birth date were retrieved from the Biobank (n = 972). Level of 25-hydroxyvitamin D (25[OH]D) in the DBSS was measured using liquid chromatography tandem mass spectroscopy. The association between different levels of 25(OH)D and risk of MS was evaluated by odds ratios (OR) calculated in conditional logistic regression models.
We observed that lower levels of 25(OH)D in neonates were associated with an increased risk of MS. In the analysis by quintiles, MS risk was highest among individuals in the bottom quintile (<20.7 nmol/L) and lowest among those in the top quintile of 25(OH)D (≥48.9 nmol/L), with an OR for top vs bottom of 0.53 (95% confidence interval [CI] 0.36-0.78). In the analysis treating 25(OH)D as a continuous variable, a 25 nmol/L increase in neonatal 25(OH)D resulted in a 30% reduced risk of MS (OR 0.70, 95% CI 0.57-0.84).
Low concentrations of neonatal vitamin D are associated with an increased risk of MS. In light of the high prevalence of vitamin D insufficiency among pregnant women, our observation may have importance for public health.
PMID: 27903815 PMCID: PMC5200855 [Available on 2018-01-03] DOI: 10.1212/WNL.0000000000003454