The effect of a single, large bolus of vitamin D in healthy adults over the winter and following year: a randomized, double-blind, placebo-controlled trial.
Eur J Clin Nutr. 2015 Feb;69(2):193-7. doi: 10.1038/ejcn.2014.209. Epub 2014 Oct 1.
Kearns MD 1, Binongo JN 2, Watson D 2, Alvarez JA 1, Lodin D 1, Ziegler TR 1, Tangpricha V 3
1 Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA, USA.
2 Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Atlanta, GA, USA.
3  Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA, USA  Atlanta Veterans Affairs Medical Center, Section of Endocrinology, Atlanta, GA, USA.
Although single, high doses of vitamin D effectively maintain vitamin D sufficiency in several populations, no studies have evaluated healthy adults over winter, during which vitamin D status declines. This study investigated whether high-dose vitamin D3 given once to healthy adults before winter will (1) prevent the wintertime decline in vitamin D status, (2) promote vitamin D sufficiency 1 year following the dose and (3) prevent the rise of parathyroid hormone (PTH) concentrations.
In this double-blind, placebo-controlled trial, we assessed plasma 25(OH)D and PTH concentrations at baseline, 5, 90 and 365 days after drug administration in 28 healthy adults. In all, >80% of subjects returned at each time point.
At baseline, the young, healthy participants had a mean plasma 25(OH)D concentration of 17.5±6.1 ng/ml. Only two subjects exhibited plasma 25(OH)D concentrations >30 ng/ml. At 5 days, subjects randomized to vitamin D3 had a higher mean plasma 25(OH)D concentration compared with the placebo group (39.1 vs 19.1 ng/ml, P<0.001). Plasma 25(OH)D concentrations returned to baseline at 90 and 365 days in the vitamin D3 group and remained unchanged in the placebo group. PTH and calcium concentrations were unrelated to changes in 25(OH)D levels and similar between groups over time.
A dose of 250,000 IU of vitamin D3 given once in November resulted in a robust increase in plasma 25(OH)D after 5 days, but it was unable to sustain this increase after 90 days. A larger or more frequent dosing regimen may be needed for long-term vitamin D sufficiency.
- 200,000 IU restored levels in HIV children having low vitamin D - Nov 2014
- Long time between large vitamin D injections resulted in 6X increase in health complaints – April 2014
- Single 300,000 IU Vitamin D dose lasts about 2 months– Nov 2016
- Injection of 300,000 IU of vitamin D3 similar to 10 months of oral 25,000 IU – Jan 2014
Injection lasts a lot longer than oral
- Overview Loading of vitamin D
Take vitamin D3 daily, weekly, or bi-weekly has the following charts
Notional chart for Vitamin D supplementation for levels < 30 nanograms
Response to a single dose of 100,000 IU starting at 27 ng/ml, half life is about 50 days
Loading dose of 300,000 IU of vitamin D does not last long – March 2014 -has the following chart