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Vitamin D – individual responses to 100,000 IU – March 2017

Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency

Clinical Chemistry and Laboratory Medicine (CCLM) .Online: 2017-03-22 |
DOI: https://doi.org/10.1515/cclm-2016-1129

Blood level Vitamin D - before and 4 weeks after oral dose

52% achieved levels > 30 ng; approximate 20 ng increase - with lots of variability

Active Vitamin D - before and 4 weeks after oral dose


See also VitaminDWiki

Response to single 20,000 IU
Reasons for low response to vitamin D ~40 reasons
Overview Loading of vitamin D has the following
Response to a single dose of 100,000 IU starting at 27 ng/ml, half life is about 50 days
see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=1046

People in this study were not obese - obese would have has lower responses

  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study

Large dose of vitamin D (200,000 IU) lasts for about 100 days – Feb 2015

200,000 IU

 Download the PDF from VitaminDWiki

We investigate the effect of a high dose of vitamin D3 on circulating concentrations of 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in healthy individuals with self-perceived fatigue and vitamin D insufficiency [25(OH)D3<50 nmol/L].

One hundred and seven study participants (age 20–50 years) were randomized to receive a single 100,000 IU dose of vitamin D3 (n=52) or placebo (n=55). Vitamin D metabolite concentrations in serum were measured before, and 4 weeks after, supplementation.

Overall, 52% of participants receiving vitamin D3 attained a serum 25(OH)D3 level >75 nmol/L. Among individuals who received vitamin D3, there were significant increases in serum concentrations of 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 at 4 weeks; however, inter-individual variability in these changes was substantial. Positive correlations between serum 25(OH)D3 and 24,25(OH)2D3 and 3-epi-25(OH)D3, and a significant negative correlation between serum 1,25(OH)2D3 and 3-epi-25(OH)D3, were found 4 weeks after supplementation. The 24,25(OH)2D3/25(OH)D3 and 24,25(OH)2D3/1,25(OH)2D3 ratios were significantly increased, compared with baseline, in participants receiving vitamin D3. Baseline 25(OH)D3 concentration was the only factor predictive of the change in 25(OH)D3 after supplementation.

Administration of a single high dose of vitamin D3 leads to a significant increase in concentrations of 25(OH)D3, 24,25(OH)2D3, 3-epi-25(OH)D3 and 1,25(OH)2D3; induction of the catabolic pathway predominates over the production of 1,25(OH)2D3. Due to the high inter-individual variation in the 25(OH)D3 response to supplementation, any given dose of vitamin D is unlikely to achieve optimal vitamin D status in all treated individuals

Attached files

ID Name Comment Uploaded Size Downloads
7873 100,000 1,25.jpg admin 23 Mar, 2017 13:11 28.80 Kb 1065
7872 100,000.pdf PDF 2017 admin 23 Mar, 2017 13:10 1.12 Mb 866