Vitamin D in Vascular Calcification: A Double-Edged Sword?
Nutrients 2018, 10(5), 652; https://doi.org/10.3390/nu10050652
Jeffrey Wang 1, Jimmy J. Zhou 1,2, Graham R. Robertson 3 and Vincent W. Lee 1
1 Centre for Transplantation and Renal Research, Westmead Institute of Medical Research, Westmead, NSW 2145, Australia
2 Centre for Kidney Research, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia
3 Cellmid Limited, 2/55 Clarence St, Sydney, NSW 2000, Australia
This study appears to ignore Vitamin K2, Magnesium, Omega-3, etc.
- Vascular calcification greatly reduced by 3 per week 1000 ug of Vitamin K2 MK-7 – Dec 2013
- Vitamin K2-7 decreases arterial stiffness (cleans arteries) – RCT Feb 2015
- Arterial stiffness reduced by Omega-3, Vitamin D, Vitamin K2, Magnesium, etc
Cardiovascular category starts with the following
Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and Vitamin D - many studies statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
 Download the PDF from VitaminDWiki
Vascular calcification (VC) as a manifestation of perturbed mineral balance, is associated with aging, diabetes and kidney dysfunction, as well as poorer patient outcomes. Due to the current limited understanding of the pathophysiology of vascular calcification, the development of effective preventative and therapeutic strategies remains a significant clinical challenge. Recent evidence suggests that traditional risk factors for cardiovascular disease, such as left ventricular hypertrophy and dyslipidaemia, fail to account for clinical observations of vascular calcification. Therefore, more complex underlying processes involving physiochemical changes to mineral balance, vascular remodelling and perturbed hormonal responses such as parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) are likely to contribute to VC. In particular, VC resulting from modifications to calcium, phosphate and vitamin D homeostasis has been recently elucidated. Notably, deregulation of vitamin D metabolism, dietary calcium intake and renal mineral handling are associated with imbalances in systemic calcium and phosphate levels and endothelial cell dysfunction, which can modulate both bone and soft tissue calcification. This review addresses the current understanding of VC pathophysiology, with a focus on the pathogenic role of vitamin D that has provided new insights into the mechanisms of VC.
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