Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Individuals With Diabetes
Diabetes Care, . 2020 Nov 8;dc201485., doi: 10.2337/dc20-1485. .
Zhenzhen Wan 1 2, Jingyu Guo 3, An Pan 4, Chen Chen 4, Liegang Liu 5 2, Gang Liu 5 2
- Diabetics with high vitamin D have 40 pcnt less all-cause mortality – Nov 2020
- Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014
- Diabetics were 4.4 X more likely to die if they had low Vitamin D – July 2018
- Vitamin D protects against many types of health problems – review May 2013
- Less than 30 ng vitamin D greatly increased hazard of dying and diabetes – Nov 2010
- Diabetics are 2X more likely to die if severely vitamin D deficient -May 2010
- Table of outcomes for seniors vs vitamin D level
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
477 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
23 ; Intervention 51 ; Meta-analysis 34 ; Obesity 28 ; Pregnancy 40 ; T1 (child) 37 ; Omega-3 11 ; Vitamin D Receptor 21 ; Genetics 11 ; Magnesium 19 Click here to see details
Objective: The evidence regarding vitamin D status and mortality among diabetes is scarce. This study aimed to examine the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among adults with diabetes.
Research design and methods: This study included 6,329 adults with diabetes from the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES 2001-2014. Death outcomes were ascertained by linkage to National Death Index records through 31 December 2015. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% CIs for mortality from all causes, cardiovascular disease (CVD), and cancer.
Results: The weighted mean (95% CI) level of serum 25(OH)D was 57.7 (56.6, 58.8) nmol/L, and 46.6% had deficient vitamin D (<50 nmol/L [20 ng/mL]). Higher serum 25(OH)D levels were significantly associated with lower levels of glucose, insulin, HOMA of insulin resistance, HbA1c, blood lipids, and C-reactive protein at baseline (all P trend < 0.05). During 55,126 person-years of follow-up, 2,056 deaths were documented, including 605 CVD deaths and 309 cancer deaths.
After multivariate adjustment, higher serum 25(OH)D levels were significantly and linearly associated with lower all-cause and CVD mortality: there was a
- 31% reduced risk of all-cause mortality and a
- 38% reduced risk of CVD mortality
per one-unit increment in natural log-transformed 25(OH)D (both P < 0.001).
Compared with participants with 25(OH)D <25 nmol/L, the multivariate-adjusted HRs and 95% CI for participants with 25(OH)D >75 nmol/L were
- 0.59 (0.43, 0.83) for all-cause mortality (P trend = 0.003),
- 0.50 (0.29, 0.86) for CVD mortality (P trend = 0.02), and
- 0.49 (0.23, 1.04) for cancer mortality (P trend = 0.12).
Conclusions: Higher serum 25(OH)D levels were significantly associated with lower all-cause and CVD mortality. These findings suggest that maintaining adequate vitamin D status may lower mortality risk in individuals with diabetes.Diabetics with high vitamin D have 40 pcnt less all-cause mortality – Nov 2020
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