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- 3+ VitaminDWiki pages with BLADDER not CANCER in title
- Overactive bladder 4.4X more-likely if low vitamin D - Meta-analysis May 2023
- See also VitaminDWiki
- 33,000 responses to medical query for (bladder -cancer) "vitamin D"
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3+ VitaminDWiki pages with BLADDER not CANCER in title
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Overactive bladder 4.4X more-likely if low vitamin D - Meta-analysis May 2023
Vitamin D levels and the risk of overactive bladder: a systematic review and meta-analysis
Nutr Rev. 2023 May 17;nuad049. doi: 10.1093/nutrit/nuad049
Qiang Zhang 1 2 3, Zhicheng Zhang 1 2 3, Xueyu He 1 2 3, Zhenmin Liu 1 2 3, Lianju Shen 1 2 3, Chunlan Long 1 2 3, Guanghui Wei 1 2 3, Xing Liu 1 2 3 4, Chunming Guo 5
Context: Overactive bladder is treated mainly with behavioral and drug therapy, and symptoms of urinary frequency and incontinence are challenging to eliminate. There is thus a continuous unmet need for new drugs with a substitution effect mechanism.
Objective: It not known whether vitamin D deficiency can lead to overactive bladder or urinary incontinence or whether vitamin D supplementation alleviates bladder symptoms. This comprehensive systematic review with meta-analysis was conducted to determine whether overactive bladder is associated with vitamin D deficiency.
Data sources: The PubMed and Cochrane Library databases were searched systematically up to July 3, 2022.
Data extraction: Initially, 706 articles were identified in the literature search, of which 13 were included in the systematic review: 4 randomized controlled trials, 3 cohort studies, 3 cross-sectional studies, and 3 case-control studies.
Data analysis: An increased risk of overactive bladder and urinary incontinence was observed with vitamin D deficiency (odds ratio OR = 4.46; 95%CI, 1.03-19.33; P = 0.046 and OR = 1.30; 95%CI, 1.01-1.66; P = 0.036, respectively). Vitamin D levels were relatively low in patients with overactive bladder or urinary incontinence (SMD = -0.33; 95%CI, -0.61 to -0.06, P = 0.019).
On the basis of existing data, the risk of urinary incontinence was reduced by 66% after vitamin D supplementation (OR = 0.34; 95%CI, 0.18-0.66; P = 0.001). Egger test was conducted to assess publication bias, and the results were tested for robustness using a sensitivity analysis.
Conclusions: Vitamin D deficiency increases the risk of overactive bladder and urinary incontinence, and vitamin D supplementation reduces the risk of urinary incontinence. The development of new strategies to prevent or alleviate bladder symptoms is crucial. Vitamin D supplementation may be gaining recognition as an effective strategy for prevention or alleviation of bladder symptoms such as overactive bladder and incontinence.
Systematic review registration: PROSPERO registration no. CRD42022351443.
See also VitaminDWiki
33,000 responses to medical query for (bladder -cancer) "vitamin D"
- Vitamin D levels and the risk of overactive bladder: a systematic review and meta-analysis May 2023 https://doi.org/10.1093/nutrit/nuad049
- Overactive bladder and associated psychological symptoms: A possible link to vitamin D and calcium - March
- The effect of vitamin D deficiency in children with overactive bladder related urinary incontinence - Apr 2022 • https://doi.org/10.1590/S1677-5538.IBJU.2021.0645 FREE PDF
- The effect of vitamin D deficiency and supplementation on urinary incontinence: scoping review - 2022 https://doi.org/10.1007/s00192-021-04963-z FREE PDF
- Vitamin D intake and the 10-year risk of urgency urinary incontinence in women - May 2020 https://doi.org/10.1016/j.jsbmb.2020.105601FREE PDF
- Vitamin D Intake and Progression of Urinary Incontinence in Women - April 2021 https://doi.org/10.1016/j.urology.2020.04.090 FREE PDF
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