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Urinary tract infection in children strongly associated with low vitamin D – Feb 2015

The Association between Vitamin D Levels and Urinary Tract Infection in Children

Horm Res Paediatr , (DOI:10.1159/000370046)
Tekin M.a drmehmettekin at hotmail.com · Konca C.a · Celik V.a · Almis H.a · Kahramaner Z.a, b · Erdemir A.a, b · Gulyuz A.d · Uckardes F.c · Turgut M.a
aDepartment of Pediatrics, bNeonatology Clinic, Department of Pediatrics, cDepartment of Statistics, School of Medicine, Adiyaman University, Adiyaman, and dDepartment of Pediatrics, Sevgi Hospital, Malatya, Turkey

Aim: We aimed to examine whether there is any association between serum levels of 25-hydroxyvitamin D [25(OH)D3] and urinary tract infection (UTI) among children.

Methods: White blood cell count, serum C-reactive protein, calcium, phosphorus, alkaline phosphatase, parathormone, and serum 25(OH)D3 levels were measured in 82 children experiencing a first episode of UTI, with no risk factors for UTI, and 64 healthy control children.

Results: The mean serum levels of 25(OH)D3 among children with UTI were significantly lower than those of controls (11.7 ± 3.3 vs. 27.6 ± 4.7 ng/ml; p < 0.001). The serum levels of 25(OH)D3 were significantly lower in patients with acute pyelonephritis compared to patients with lower UTI (8.6 ± 2.8 vs. 14.2 ± 3.0 ng/ml; p < 0.001). Within the study group, mean serum levels of 25(OH)D3 among girls were lower than those of boys (10.9 ± 3.4 ng/ml vs. 13.2 ± 4.4 ng/ml; p < 0.001). Multivariate analysis showed that a serum 25(OH)D3 level of <20 ng/ml (odds ratio 3.503, 95% confidence interval 1.621-7.571; p = 0.001) was associated with UTI in children.

Conclusions: Our results suggest that vitamin D deficiency may be a risk factor for UTI in children.

See also VitaminDWiki