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Overactive bladder 32 X more likely if very low vitamin D – April 2019

Neurourol Urodyn. 2019 Apr;38(4):1160-1167. doi: 10.1002/nau.23975. Epub 2019 Mar 14.
Abdul-Razzak KK1, Alshogran OY1, Altawalbeh SM1, Al-Ghalayini IF2, Al-Ghazo MA2, Alazab RS2, Halalsheh OM2, Sahawneh FE2.

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INTRODUCTION:
Overactive bladder (OAB) is a prevalent syndrome that is associated with multiple urinary tract symptoms and could affect the patient's quality of life and well-being. Vitamin D is shown to be linked to OAB syndrome, which exacerbated by stress conditions. This study evaluated the relationship between vitamin D status, daily calcium intake and OAB, and the associated psychological symptoms.

METHODS:
The study included 55 patients with OAB and 129 healthy controls. Psychological symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Serum vitamin D was measured. Patients with OAB with low vitamin D level received orally vitamin D supplementation. Urinary symptoms, psychological symptoms, and quality of life were evaluated before and after vitamin D supplementation plus dairy products.

RESULTS:
Vitamin D deficiency was more prevalent in

  • cases (80%) vs controls (34.9%).
  • Depression (43.7% vs 20.2%) and
  • anxiety (52.8% vs 10.9%) scores (HADS, ≥8) were also more frequent in cases vs controls, respectively.
  • Some 85.5% of the patients' group had musculoskeletal pain vs 0.0% for the control.

Depression was negatively correlated with daily calcium intake and positively with anxiety. Logistic regression analysis revealed that age, vitamin D, and anxiety scores were significant predictors of OAB. Vitamin D supplements with increased calcium intake had significant improvement in urinary symptoms, psychological distress, and quality of life.

CONCLUSIONS:
Vitamin D supplements and improved calcium intake may improve urinary and psychological symptoms and quality of life among patients with OAB syndrome. Assessment for vitamin D status in patients with OAB may be warranted.

Created by admin. Last Modification: Sunday July 7, 2019 18:16:11 GMT-0000 by admin. (Version 8)

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12283 Overactive vs. age.jpg admin 07 Jul, 2019 18:12 23.86 Kb 22
12282 Overactive bladder.jpg admin 07 Jul, 2019 17:44 42.33 Kb 24
12281 Overactive Bladder 32X.pdf PDF 2019 admin 07 Jul, 2019 17:44 316.63 Kb 19
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