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Based on PTH response, obese adolescents may not need and much vitamin D as non-obese (12 ng vs 16.5 ng) – June 2021

Different threshold levels of circulating total and free 25-hydroxyvitamin D for the diagnosis of vitamin D deficiency in obese adolescents

Eur J Pediatr. 2021 Jun 11. doi: 10.1007/s00431-021-04137-5
Nurullah Çelik 1, Halef Okan Doğan 2, Gökmen Zararsiz 3 4


The response of the parathyroid hormone (PTH) is about the only way to determin that vitamin D is actually getting to cells

Vitamin D titles containing PTH OR Parathyroid

Items found: 44
Title Modified
Preterm birth 7 X more likely if both low vitamin D and high PTH 1 month before birth – May 2023 23 May, 2023
Vitamin D dosing varies with genes, PTH, Mg, Vit K, etc – video and transcript Sept 2022 29 Dec, 2022
PTH and Vitamin D - many studies 29 Dec, 2022
Maasai have PTH and bone resorption (CTX) circadian rhythms – April 2022 29 Apr, 2022
PTH failed to decrease with Vitamin D if overweight and had low Magnesium – Aug 2019 04 Mar, 2022
Parathyroid response to Vitamin D among obese 27 Jun, 2021
Based on PTH response, obese adolescents may not need and much vitamin D as non-obese (12 ng vs 16.5 ng) – June 2021 12 Jun, 2021
Parathyroid Hormone levels increase 63 percent with age (33,000 people) – Sept 2017 17 May, 2021
Parathyroid hormone level is inversely associated with both Vitamin D and age – April 2021 17 May, 2021
High PTH plus low Vitamin D is not good (5X more likely for COPD to need hospital) – April 2021 25 Apr, 2021
Increased Colorectal cancer risk if Vitamin D does not lower PTH (Vit D not getting to cells) – Nov 2020 06 Nov, 2020
ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015 06 Jun, 2020
Parathyroid increase with age associated with worsening Vitamin D genes – April 2020 01 May, 2020
Worse diabetic vision is associated with low vitamin D or high PTH - Nov 2012 07 Jan, 2020
Parathyroid – Vitamin D inflection points might be at both 16 and 32 ng – Oct 2019 04 Oct, 2019
Hip fractures worse if both high PTH and low Vitamin D – Jan 2019 01 Feb, 2019
Interview of Dr. Coimbra: MS, Autoimmune, Vitamin D, B2, Ca, Mg, PTH etc. – perhaps 2018 02 Dec, 2018
Heart Failure is predicted by PTH (but vitamin D both prevents and treats HF) – Jan 2018 31 Mar, 2018
Coronary Heart Disease 57 percent more likely if poor Vitamin D Binding Protein with high PTH – Nov 2017 08 Nov, 2017
Thyroid and parathyroid 12 Sep, 2017
Ischemic Stroke risk best predicted by Vitamin D, including PTH improves the prediction – Feb 2017 02 Mar, 2017
Critically ill injected with 300,000 IU of vitamin D, 3X more likely to die if PTH did not respond - RCT July 2015 22 Jan, 2017
3000 IU of vitamin D minimum to reduce parathyroid hormone (PTH) – meta-analysis Sept 2015 10 Dec, 2016
Need 40 ng of vitamin D to have proper PTH levels – May 2011 29 Mar, 2016
PTH boosts immune response when vitamin D levels are low – May 2012 29 Mar, 2016
PTH does not plateau with increasing vitamin D, but does decrease with patient age – Aug 2012 29 Mar, 2016
Hypothesis Vitamin D receptor controls PTH without needing Vitamin D – Aug 2015 01 Sep, 2015
Knee Osteoarthritis 3.2X more likely to get worse if low Vitamin D and high PTH – Dec 2014 23 Feb, 2015
PTH reduced 3.5 pmol by vitamin D intervention which added 22 ng – meta-analysis June 2014 01 Jan, 2015
Diabetes after giving birth was associated with low vitamin D combined with high PTH – May 2014 31 May, 2014
2800 IU of vitamin D before and after parathyroid surgery helped a lot – RCT Jan 2014 16 Jan, 2014
ICU reduces Vitamin D levels, deregulates PTH - Sept 2013 28 Sep, 2013
Almost 3X more likely to get preeclampsia if low vitamin D and high PTH– July 2013 15 Sep, 2013
Vitamin D deficiency for children’s bones is 14ng, based on PTH analysis – Sept 2013 09 Sep, 2013
Japanese decided that 28 ng mimimum for proper parathyroid hormone – June 2010 09 Sep, 2013
PTH needs vitamin D level higher than 13 ng – Cohort June 2010 09 Sep, 2013
Children have PTH problems when vitamin D is less than 15 ng – Nov 2011 09 Sep, 2013
Variations in Parathyroid Hormone Concentrations in Patients with Low Vitamin D – June 2012 09 Sep, 2013
Hypothesis: Not vitamin D deficient if have normal PTH and BMD – May 2013 01 Jun, 2013
1000 IU of vitamin D reduced child PTH, but did not increase Calcium – RCT Jan 2013 03 Jan, 2013
Chronic kidney disease and PTH – Calcium – Phosphate – Vitamin D – April 2011 23 May, 2012
20 ng of vitamin D is enough for African American PTH – Dec 2011 09 Mar, 2012
Africans in Europe might only need 19 ng of vitamin D – estimated from PTH July 2011 09 Mar, 2012
Blacks may need less vitamin D than whites – PTH Aug 2010 23 Dec, 2011

The total serum 25-hydroxyvitamin D [25(OH)DT] level is lower in obese individuals than in their nonobese peers, despite similar bone turnover markers and bone mineral density. This study aimed to investigate whether the threshold level of 25(OH)D for the diagnosis of vitamin D deficiency (VDD) in obese adolescents was lower than that in controls and to compare 25(OH)DT, free [25(OH)DF] and bioavailable [25(OH)DB] vitamin D with VDBP levels in obese individuals and their controls.

A total of 173 adolescents (90 obese individuals and 83 controls) aged 12-18 years were included in the study. The metabolic and anthropometric parameters of the participants were recorded, the 25(OH)DT, 25(OH)DF, and VDBP levels were measured, and the 25(OH)DB levels were calculated. The cutoff values for VDD were estimated according to the level of 25(OH)D below which parathyroid hormone begins to rise.
The obese subjects had lower

  • 25(OH)DT (12.1 ± 5.8 vs. 16.4 ± 9.3 ng/mL, p < 0.001),
  • 25(OH)DF (12.6 ± 4.2 vs. 16.7 ± 7.6 pg/mL, p < 0.001),
  • 25(OH)DB [4.8 (2.3) vs. 6.1 (5.2) ng/mL, p = 0.012], and
  • VDBP [112.2 (51.3) vs. 121.9 (95.5) μg/mL, p < 0.001] levels than the controls.

The cutoff values for 25(OH)DT and 25(OH)DF levels for VDD were lower in the obese group than in the control group (9.4 vs. 14.1 ng/mL; 12.2 vs. 16.8 pg/mL, respectively).

Conclusion: The vitamin D cutoff values for the diagnosis of VDD were different in the obese and control groups. Using the same cutoff value for VDD may cause overtreatment in obese adolescents.

What is Known:

  • Vitamin D deficiency is more prevalent in obese children than nonobese controls,
    • despite the same bone turnover markers and bone mineral density
  • The cutoff value of vitamin D level for the diagnosis of VDD is based on the PTH elevation

What is New

  • In obese adolescents, total and free vitamin D cutoff value for the diagnosis of VDD was lower than nonobese peers


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