The Role of Parathyroid Hormone and Vitamin D Serum Concentrations in Patients with Cardiovascular Diseases.
Dis Markers. 2018 Jan 31;2018:5287573. doi: 10.1155/2018/5287573. eCollection 2018.
Kolaszko A1, Nowalany-Kozielska E1, Ceranowicz P2, Morawiec B1, Kubiak G1.
1 2nd Department of Cardiology, Medical Faculty, Medical University of Silesia, Katowice 10 M. Skłodowskiej-Curie Street, 41-800 Zabrze, Poland.
2 Department of Physiology, Medical Faculty, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, Poland.
Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis Oct 2015
Risk of Cardiac failure reduced 20 percent by 800 IU of vitamin D and Calcium – meta-analysis July 2014
Chronic Heart Failure improved with 4,000 IU daily for a year – RCT April 2016
Seniors with Heart Failure helped by daily 4,000 IU of vitamin D (increase 16 ng) – RCT Aug 2014
Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
Heart Failure Quality of Life greatly improved by 10,000 IU of vitamin D – RCT Oct 2017
Heart failure among 137 seniors 12X more likely if low vitamin D – Aug 2017
PTH reduced 3.5 pmol by vitamin D intervention which added 22 ng – meta-analysis June 2014
Acute Heart Failure length of stay and readmission rates cut in half if high vitamin D – Aug 2017
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
25-hydroxyvitamin D (25(OH)D) plays a crucial role in human homeostasis. Its deficiency (vitamin D deficiency-VDD), being common in European population, combined with elevated concentration of parathyroid hormone (PTH), represents a vicious cycle of mechanisms leading to heart failure (HF). Despite several papers published in that field, the effect of VDD and PTH concentration on cardiovascular system remains unequivocal; thus, the aim of the study was to compare these data among HF and non-HF patients being prospectively enrolled into the study during hospital stay in the cardiology ward.
Patients with HF had higher PTH concentration (85.0 ± 52.6 versus 64.5 ± 31.7, p ≤ 0.02) compared to non-HF patients.
Mean PTH values were associated with the clinical status expressed by the New York Heart Association class (NYHA class)
- "III"-85.59, and
- "IV"-144.37 pg/ml, p ≤ 0.00004).
- neither 25(OH)D (31.5 versus 29.7 ng/ml, p ≤ ns)
- nor phosphorus (P) (1.23 versus 1.18 mmol/l, p ≤ ns)
- nor total calcium (Ca2+) concentration (2.33 versus 2.37 mmol/l, p ≤ ns)
differed among the groups.
Reassuming PTH serum concentration in contrary to 25(OH)D, P and Ca2+ are significantly raised among the patients with HF and shows significant relationship with the clinical status expressed by the NYHA class.
PMID: 29599854 PMCID: PMC5831602 DOI: 10.1155/2018/5287573