Diabetic Retinopathy severity Serum vitamin D and parathormone (PTH) concentrations as predictors of the development and severity of diabetic retinopathy
Rania Naguib Abdel Mouteleb Abdel Reheem ranianaguib2000 at yahoo.com, Maaly Abdel Halim Mohamed Abdel Fattah mola_73 at hotmail.com
Received 14 April 2012; accepted 24 August 2012. published online 08 October 2012.
Background: Vitamin D is suggested to be an inhibitor of angiogenesis. The degree of severity of diabetic retinopathy (DR) may be related to serum vitamin D concentration.
Aim: Investigating vitamin D and parathormone (PTH) concentrations as predictors of the development and severity of diabetic retinopathy.
Methods: Two hundred diabetic patients presenting with suspected diabetic retinopathy were investigated, levels of vitamin D [25(OH) D3 and Calcitriol] and PTH were measured.
Diabetic retinopathy was assessed using 7-field stereoscopic Fundus photography.
Results: Mean serum concentration of 1, 25 dihydroxy vitamin D 3 (1, 25(OH) 2 D3) was significantly lower in diabetic subjects with retinopathy than in diabetic subjects with no retinopathy and there is a significant negative correlation between the mean level of 1, 25(OH) 2 D3 and the degree of severity of retinopathy.
Level of PTH was significantly higher in severe NPDR and PDR compared to patients with no retinopathy.
Conclusions: Low levels of vitamin D might be a risk marker of development or progression of diabetic retinopathy. It might be advisable that detailed ophthalmologic examination is needed for diabetics whose serum 1, 25(OH) 2D3 concentrations gradually decreased. The measurement of serum 1, 25(OH) 2 D3 concentrations could become a useful biochemical means to predict the severity of DR in patients with diabetes mellitus.
Our study revealed no correlation between the mean serum 25(OH) D and the degree of retinopathy. (from the PDF)
That is, blood levels of vitamin D did not vary with the severity of diabetic vision problem.
PDF is attached at the bottom of this page
- Vitamin D3 becomes Calcidiol which becomes Calcitriol
Lots of information, such as: short time constant, much more expensive than Vitamin D, probably needed when liver is not working well
Has many charts, such as
The items in both Diabetes and Vision are listed here:
- Diabetic Retinopathy twice as likely if a T2 Diabetic has low level of vitamin D – meta-analysis March 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Diabetic Retinopathy 27 percent more likely if low vitamin D – meta-analysis May 2016
- Diabetic Neuropathy sometimes can be reversed by vitamin D
- Worse diabetic vision is associated with low vitamin D or high PTH - Nov 2012
- Diabetics have more retina problems as they have less vitamin D – Sept 2011
- Vitamin D Deficiency Associated With Common Cause of Blindness Live in the now, Nov 2012
Review of this study - which resulted in this web page on VitaminDWiki
The disease has four main stages:
0. No retinopathy (21%)
1. Mild Non-proliferative Retinopathy: This is the earliest stage, where small areas of swelling occur in the blood vessels. (19%)
2. Moderate Non-proliferative Retinopathy: At this stage, some blood vessels in the retina become blocked. (17%)
3. Severe Non-proliferative Retinopathy: many blood vessels become blocked and the retina starts to become deprived of blood supply. (20%)
4. Proliferative Retinopathy: The most advanced stage (22%)
growth of abnormal new blood vessels which are extremely thin-walled and fragile ==>highly susceptible to leakage ==> blindness.
There have actually been
Short url = http://is.gd/diabeticvision
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