Fluctuations in clinical symptoms with changes in serum 25(OH) vitamin D levels in autistic children: Three cases report.
Nutr Neurosci. 2018 Apr 8:1-4. doi: 10.1080/1028415X.2018.1458421. [Epub ahead of print]
Jia F1,2,3, Shan L1, Wang B1, Li H1, Feng J1, Xu Z4, Saad K1,5.
1 Dept of Developmental and Behavioral Pediatrics , The First Hospital of Jilin Univ. , Changchun 130021 , People's Republic of China.
2 Institute of Pediatrics of First Hospital of Jilin University , Changchun 130021 , People's Republic of China.
3 Neurological Research Center of First Hospital of Jilin University , Changchun 130021 , People's Republic of China.
4 Department of Psychiatry , University Medical Center Utrecht , Netherlands.
5 Pediatric Department, Faculty of Medicine , Assiut University , Assiut , Egypt.
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
Note - one of the subjects in current study was treated by 150,000 IU monthly injections - symptoms worsen when no injections
- Autistic children were 3.6 X more likely to have low levels of vitamin D – Nov 2017
- Autistic children have lower levels of Iron, Vitamin D, Magnesium, etc – Oct 2017
- Vitamin D and autism - treat: 300 IU per kg per day, prevent: during pregnancy 5,000 IU – Feb 2017
- Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention – April 2016
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by complicated interactions between genetic and environmental factors. Clinical trials, including case reports, case-control studies, and a double-blinded randomized clinical study, have suggested that high-dose vitamin D3 regimens may ameliorate the core symptoms of ASD. Vitamin D3 supplementation was effective in about three-quarters of children with ASD. To further investigate the relationship between vitamin D and ASD symptoms in vitamin D-responsive autistic children, changes in symptoms were assessed in three children with ASD who were given vitamin D3 supplementation followed by a long interruption.
The core symptoms of ASD were remarkably improved during the vitamin D3 supplementation period when serum 25-hydroxyvitamin D [25(OH)]D levels reached over 40.0 ng/mL.
However, symptoms reappeared after the supplementation was stopped, when serum 25(OH)D levels fell below 30.0 ng/mL but were again improved with re-administration of vitamin D3 after the interruption, when serum 25(OH)D levels exceeded 40.0 ng/mL.
Overall, these results showed that the core symptoms of ASD fluctuated in severity with changes in serum 25(OH)D levels in children, indicating that maintaining a responsive 25(OH)D level is important for treating ASD. Maintaining a serum 25(OH)D level between 40.0 and 100.0 ng/ml may be optimal for producing therapeutic effects in vitamin D-responsive individuals with ASD.
PMID: 29629638 DOI: 10.1080/1028415X.2018.1458421