Improving the Vitamin D Status of Vitamin D Deficient Adults Is Associated With Improved Mitochondrial Oxidative Function in Skeletal Muscle
The Journal of Clinical Endocrinology & Metabolism March 1, 2013 vol. 98 no. 3 E509-E513
Akash Sinha, Kieren G. Hollingsworth, Steve Ball and Tim Cheetham t.d.cheetham at ncl.ac.uk
Department of Paediatric Endocrinology (A.S., T.C.), Great North Children's Hospital, and Department of Endocrinology (S.B.), Royal Victoria Infirmary, NE1 4LP Newcastle-upon-Tyne, United Kingdom; Institute of Genetic Medicine (A.S., S.B., T.C.), Newcastle University, Newcastle-upon-Tyne NE1 7RU, United Kingdom; and Newcastle Magnetic Resonance Centre (K.G.H.), Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne NE4 5PL, United Kingdom
Objective: Suboptimal mitochondrial function has been implicated in several disorders in which fatigue is a prominent feature. Vitamin D deficiency is a well-recognized cause of fatigue and myopathy. The aim of this study was to examine the effects of cholecalciferol therapy on skeletal mitochondrial oxidative function in symptomatic, vitamin D-deficient individuals.
Design: This longitudinal study assessed mitochondrial oxidative phosphorylation in the gastrosoleus compartment using phosphorus-31 magnetic resonance spectroscopy measurements of phosphocreatine recovery kinetics in 12 symptomatic, severely vitamin D-deficient subjects before and after treatment with cholecalciferol. All subjects had serum assays before and after cholecalciferol therapy to document serum 25-hydroxyvitamin D (25OHD) and bone profiles. Fifteen healthy controls also underwent 31P-magnetic resonance spectroscopy and serum 25OHD assessment.
Results: The phosphocreatine recovery half-time (τ1/2PCr) was significantly reduced after cholecalciferol therapy in the subjects indicating an improvement in maximal oxidative phosphorylation (34.44 ± 8.18 sec to 27.84 ± 9.54 sec, P < .001). This was associated with an improvement in mean serum 25OHD levels (8.8 ± 4.2 nmol/L to 113.8 ± 51.5 nmol/L, P < .001). There was no difference in phosphate metabolites at rest. A linear regression model showed that decreasing serum 25OHD levels was associated with increasing τ1/2PCr (r = −0.41, P = .009). All patients reported an improvement in fatigue after cholecalciferol therapy.
Conclusions: Cholecalciferol therapy augments muscle mitochondrial maximal oxidative phosphorylation after exercise in symptomatic, vitamin D-deficient individuals. This finding suggests that changes in mitochondrial oxidative phosphorylation in skeletal muscle could at least be partly responsible for the fatigue experienced by these patients. For the first time, we demonstrate a link between vitamin D and the mitochondria in human skeletal muscle.
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Small study, giving 20,000 IU vitamin D3 every other day for 12 weeks.
I had been taking D-Ribose to recover from overexercise/muscle fatigue
Now, with >10,000 IU of vitamin D, I no longer feel very tired after intense exercise
This study shows why - Vitamin D provides the muscle recovery that I use to get only via D-Ribose
Henry Lahore, admin of VitaminDWiki, March 2013
- 11 Incredible Health Benefits of D-Ribose – with Side Effects Self-Hacked Oct 2017
1) Heart 2) Fibromyalgia, 3) Replenishes Energy Reserves. 4)Improves Muscular Strength
5) May Help with Restless Leg Syndrome, 6) ay Improve Symptoms of Adenylosuccinase Deficiency
7) May Treat Myoadenylate Deaminase Deficiency. 8) May Protect the Kidneys
9) May Protect the Brain. 10)Improve Weight Loss, 11)May Reduce Testicular Toxicity Caused by Aluminum
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(average phosphocreatine recovery half time decreased from 34.4sec to 27.8sec, p<0.001).
All patients reported an improvement in symptoms of fatigue following supplementation.
In a parallel study, the group demonstrated that low Vitamin D levels were associated with reduced mitochondrial function (r=-0.41, p=0.009).
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