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Death due to cystic fibrosis reduced about 4X due to 250000 IU of vitamin D – RCT June 2012

Pilot study of vitamin D supplementation in adults with cystic fibrosis pulmonary exacerbation: A randomized, controlled trial

Dermato-Endocrinology Volume 4, Issue 2 April/May/June 2012
Authors: Ruth E. Grossmann, Susu M. Zughaier, Meena Kumari, Shabnam Seydafkan, Robert H. Lyles, Shuling Liu, Viranuj Sueblinvong, Michael S. Schechter, Arlene A. Stecenko, Thomas R. Ziegler and Vin Tangpricha

Background: Vitamin D insufficiency is common in cystic fibrosis (CF) and vitamin D repletion may have an important role in improving clinical outcomes in CF. This randomized, placebo-controlled, pilot study examined the feasibility and impact of a single, large dose of cholecalciferol on vitamin D status and clinical outcomes in subjects with CF.

Methods: Thirty adults with were randomized in a double-blinded, pilot study to receive 250,000 IU cholecalciferol or placebo within 48 h of hospital admission for a pulmonary exacerbation. Concentrations of 25-hydroxyvitamin D (25(OH)D), clinical outcomes and potential adverse events were assessed up to 1-y after randomization. Mixed effects linear regression models were used to evaluate the difference in mean serum concentrations and log-rank analyses were used to evaluate survival.

Results: Data from all subjects was analyzed. Serum 25(OH)D concentrations increased from a mean of 30.6 ± 3.2 ng/mL to 58.1 ± 3.5 ng/mL (p < 0.001) at one week and 36.7 ± 2.6 ng/mL by 12 weeks (p = 0.06) in the vitamin D group; in contrast, serum 25(OH)D concentrations remained unchanged in the placebo group. Unadjusted, one-year survival and hospital-free days were increased in the vitamin D group (p = 0.029, p = 0.036; respectively). There was also a trend toward increased IV antibiotic therapy-free days in the vitamin D group (p = 0.073). There were no signs of hypervitaminosis D or adverse events. Serum PTH and calcium concentrations were similar across both groups.

Conclusions: In this pilot study, a single, oral bolus of cholecalciferol increased serum 25(OH)D concentrations and was associated with a trend toward improved clinical outcomes in CF subjects hospitalized for a pulmonary exacerbation. Further investigation is needed into the clinical impact of improved vitamin D status in patients with CF.

Approx 4X less risk of death due to single dose of Vitamin D

1 person in vitamin D group died vs 5 died in the placebo group

PDF is attached at the bottom of this page
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Wonder how many much less risk of death if vitamin D had been given multiple times.
Example: Give 250,000 IU vitamin D every 2 months.

Suspect that it will be difficult to get approval for a large CF RCT in the future.
The ethics committee would have a hard time allowing scores of CF deaths for the placebo group.

See also VitaminDWiki


Attached files

ID Name Comment Uploaded Size Downloads
1495 CF pilot study.jpg admin 30 Jul, 2012 10.76 Kb 3251
1494 CF pilot study Grossman - 2012.pdf admin 30 Jul, 2012 685.34 Kb 1907