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Vitamin D and chronic kidney disease – July 2014

Korean J Intern Med. Jul 2014; 29(4): 416–427.
Published online Jun 27, 2014. doi: 10.3904/kjim.2014.29.4.416
PMCID: PMC4101586
Chang Seong Kim and Soo Wan Kim

Chronic kidney disease (CKD) has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Vitamin D deficiency or insufficiency is common in patients with CKD, and serum levels of vitamin D appear to have an inverse correlation with kidney function. Growing evidence has indicated that vitamin D deficiency may contribute to deteriorating renal function, as well as increased morbidity and mortality in patients with CKD. Recent studies have suggested that treatment with active vitamin D or its analogues can ameliorate renal injury by reducing fibrosis, apoptosis, and inflammation in animal models; this treatment also decreases proteinuria and mortality in patients with CKD. These renoprotective effects of vitamin D treatment are far beyond its classical role in the maintenance of bone and mineral metabolism, in addition to its pleiotropic effects on extra-mineral metabolism. In this review, we discuss the altered metabolism of vitamin D in kidney disease, and the potential renoprotective mechanisms of vitamin D in experimental and clinical studies. In addition, issues regarding the effects of vitamin D treatment on clinical outcomes are discussed.

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Note: GFR = Glomerular Filtration Rate

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Vitamin D and chronic kidney disease – July 2014        
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4751 CKD Dec 2014.jpg admin 18 Dec, 2014 15:07 248.66 Kb 1564
4750 CKD 2014.pdf admin 18 Dec, 2014 15:02 70.81 Kb 1026
4191 CKD trials.jpg admin 26 Jul, 2014 15:52 286.76 Kb 2573
4190 CKD F1.jpg admin 26 Jul, 2014 15:52 65.65 Kb 7860
4189 CKD July 2014.pdf admin 26 Jul, 2014 15:51 471.20 Kb 753