Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D3
BioMed Research International. Volume 2018, Article ID 9329123, 9 pages, https://doi.org/10.1155/2018/9329123
Natalia Niedziela,1 natalia at niedziela.org Krystyna Pierzchała,1 Jolanta Zalejska-Fiolka,2 Jacek T. Niedziela,3 Ewa Romuk,2 Magdalena Torbus-Paluszczak,1 and Monika Adamczyk-Sowa1
- 1 Department of Neurology, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800 Zabrze, Poland
- 2 Department of Biochemistry, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland
- 3 3rd Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Silesian Centre for Heart Disease, Zabrze, Poland
Overview MS and vitamin D
Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018
Vitamin D has already cleared 100 percent of lesions from over 1,000 MS patients in Brazil
Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
Multiple Sclerosis – 3X higher incidence in women, previously 1X, wonder why
Vitamin D is the real Multiple Sclerosis Therapy, not an alternative therapy – Coimbra July 2018
Multiple Sclerosis Coimbra Protocol with Vitamin D - increased walking - May 2018
Rate of vitamin D supplementation by Blacks increases 16X after getting Multiple Sclerosis – Feb 2018
Vitamin D is the only dietary supplement which significantly benefits MS – JAMA April 2018
Background. In addition to the widely known effect of vitamin D3 (vitD3) on the skeleton, its role in the regulation of the immune response was also confirmed.
Aim. The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosis (RRMS) selected due to the serum level of vitamin D3.
Methods. The concentrations of biochemical markers and indices of lumbar spine bone densitometry (DXA) were determined in 82 patients divided into vitamin D3 deficiency (VitDd), insufficiency (VitDi), and normal vitamin D3 level (VitDn) subgroups.
Results. The highest level of the parathyroid hormone (PTH) and the highest prevalence of hypophosphatemia and osteopenia were demonstrated in VitDd group compared to VitDi and VitDn. However, in VitDd, VitDi, and VitDn subgroups no significant differences were observed in the levels of alkaline phosphatase (ALP) and ionized calcium (Ca2+) and in DXA indices. A negative correlation was observed between the level of vitamin D3 and the Expanded Disability Status Scale (EDSS) in the whole MS group. The subgroups were significantly different with respect to the EDSS scores and the frequency of complaints related to walking according to the EQ-5D.
Conclusions. It is necessary to assess calcium-phosphate metabolism and supplementation of vitamin D3 in RRMS patients. The higher the clinical stage of the disease assessed with the EDSS, the lower the level of vitamin D3 in blood serum. Subjectively reported complaints related to difficulties with walking were reflected in the EDSS in VitDd patients.
Short URL = https://is.gd/MSwalk