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Multiple Sclerosis – more gray matter and fewer relapses if 10 ng more vitamin D – Oct 2015

Vitamin D in clinically isolated syndrome: evidence for possible neuroprotection

European Journal of Neurology, Article first published online: 31 OCT 2015, DOI: 10.1111/ene.12844
E. M. Mowry1,*, D. Pelletier2, Z. Gao3, M. D. Howell3, S. S. Zamvil4 andE. Waubant4

VitaminDWiki Summary

Every 10 ng/ml more vitamin D associated with

  • 8 ml more gray matter volume
  • 35% reduction in risk of MS relapse (P = 0.096)

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Background and purpose
Vitamin D status has been associated with inflammatory activity in multiple sclerosis (MS), but it is not known if it is associated with gray matter volume, the loss of which predicts long-term disability in MS. The association of vitamin D levels with brain volume measures and inflammatory activity in patients with clinically isolated syndrome (CIS) was investigated.

Methods
In the phase 2 CIS trial of atorvastatin, 25-hydroxyvitamin D levels were evaluated for their age-adjusted associations with normalized gray matter and brain parenchymal volumes on brain magnetic resonance imaging (MRI). The relationships between 25-hydroxyvitamin D levels and clinical and MRI measures of inflammatory activity were also assessed.

Results
In 65 patients in this substudy, each 25 nmol/l higher 25-hydroxyvitamin D level was associated with 7.8 ml higher gray matter volume (95% confidence interval 1.0, 14.6, P = 0.025). There was a tendency for an inverse association of average 25-hydroxyvitamin D levels and the composite end-point of ≥3 new brain T2 lesions or ≥1 relapse within a year (odds ratio per 25 nmol/l higher 25-hydroxyvitamin D level 0.66, 95% confidence interval 0.41, 1.08, P = 0.096).

Conclusions
Vitamin D status may impact neurodegeneration after CIS, although these results should be replicated in a second study. If confirmed in clinical trials, vitamin D supplementation may reduce long-term disability.

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