Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis
J Bone Miner Metab. 2022 May 31. doi: 10.1007/s00774-022-01333-7 behind $40 paywall
Shahrzad Habibi Ghahfarrokhi 1 2, Abdollah Mohammadian-Hafshejani 2 3, Catherine M T Sherwin 4 5, Saeid Heidari-Soureshjani 6 7 8
Introduction: This study investigated the relationship between serum 25-hydroxyvitamin D (25OHD) levels and the occurrence of hip fractures in the elderly using a systematic review and meta-analysis approach.
Materials and methods: PubMed, Web of Science, and Scopus were used to identify studies that outlined an association between serum 25OHD and the occurrence of a hip fracture in a geriatric patient. The analysis calculated odds ratios (OR) for a hip fracture using a random-effects model.
Results: In this study, 28 studies were included, 61,744 elderlies and 9767 cases (15.81%) of hip fractures.
In the lowest vs. highest categories of vitamin D in the elderly, pooled OR of hip fractures was 1.80 (95% CI 1.56-2.07, P = 0.001), and
modified OR was equal to 1.40 (95% CI 1.20-1.63 P = 0.001).
A subgroup analysis showed that the OR of a hip fracture was 2.16 (1.49-3.11, P = 0.001) in case-control studies;
1.52 (1.29-1.79, P = 0.001) in cohort studies; and 1.41 (1.18-1.70, P = 0.001) in case-cohort studies.
Conclusion: Low serum vitamin D levels in the elderly are associated with an increase in the odds of hip fracture.
VitaminDWiki - Falls and Fractures category contains
236 items in FALLS and FRACTURES
- Vitamin D and Calcium cost-effectively reduce falls and fractures – April 2019
- see also Overview Seniors and Vitamin D
- Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019
- Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
- Falls reduced by a third if achieved 40 ng level vitamin D– RCT Sept 2018
- Note: Took 6 months to get to that level. Most trials last only 3 months
- Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
- Falls reduced by Vitamin D: 13 percent reduction if more than 700 IU – review of 38 trials – Aug 2022
More hip fractures if low vitamin D (2.1X in case-controlled studies) – meta-analysis May 2022
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Vitamin K (any amount and any kind) reduced bone fractures by 24 percent – meta-analysis – May 2019
- Hip fracture in VitaminDWiki title (68 as of Dec 2022) Click here for details
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