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More hip fractures if low vitamin D (2.1X in case-controlled studies) – meta-analysis May 2022

Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis

J Bone Miner Metab. 2022 May 31. doi: 10.1007/s00774-022-01333-7 behind $40 paywall
Shahrzad Habibi Ghahfarrokhi 1 2, Abdollah Mohammadian-Hafshejani 2 3, Catherine M T Sherwin 4 5, Saeid Heidari-Soureshjani 6 7 8

Introduction: This study investigated the relationship between serum 25-hydroxyvitamin D (25OHD) levels and the occurrence of hip fractures in the elderly using a systematic review and meta-analysis approach.

Materials and methods: PubMed, Web of Science, and Scopus were used to identify studies that outlined an association between serum 25OHD and the occurrence of a hip fracture in a geriatric patient. The analysis calculated odds ratios (OR) for a hip fracture using a random-effects model.

Results: In this study, 28 studies were included, 61,744 elderlies and 9767 cases (15.81%) of hip fractures.
In the lowest vs. highest categories of vitamin D in the elderly, pooled OR of hip fractures was 1.80 (95% CI 1.56-2.07, P = 0.001), and
modified OR was equal to 1.40 (95% CI 1.20-1.63 P = 0.001).
A subgroup analysis showed that the OR of a hip fracture was 2.16 (1.49-3.11, P = 0.001) in case-control studies;
1.52 (1.29-1.79, P = 0.001) in cohort studies; and 1.41 (1.18-1.70, P = 0.001) in case-cohort studies.

Conclusion: Low serum vitamin D levels in the elderly are associated with an increase in the odds of hip fracture.

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