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Fetal Growth poor if Vitamin D-Binding Protein gene poor – Feb 2017

Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction.

J Pregnancy. 2017;2017:5120267. doi: 10.1155/2017/5120267. Epub 2017 Feb 15.
Wookey AF1, Chollangi T1, Yong HE1, Kalionis B1, Brennecke SP2, Murthi P3, Georgiou HM4.


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Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (n = 9) and nonidiopathic (n = 9). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p < 0.05, Student's t-test) that were strongly associated with idiopathic fetal growth restriction (p < 0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p = 0.295, Pearson's correlation). As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.

PMID: 28293436 PMCID: PMC5331297 DOI: 10.1155/2017/5120267


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Attached files

ID Name Comment Uploaded Size Downloads
8693 Low FGR if Low VDBP.jpg admin 10 Nov, 2017 15.68 Kb 493
8692 Fetal Growth VBDP.pdf admin 10 Nov, 2017 633.76 Kb 618