Toggle Health Problems and D

Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016

Vitamin D for the treatment of painful diabetic neuropathy

Emerging technologies and therapeutics
BMJ Open Diab Res Care 2016;4:e000148 doi:10.1136/bmjdrc-2015-000148
Abdul Basit1,2, Khalid Abdul Basit1, Asher Fawwad1,2, Fariha Shaheen1, Nimra Fatima1, Ioannis N Petropoulos3, Uazman Alam4, Rayaz A Malik3,4
1Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan
2Baqai Medical University, Karachi, Pakistan
3Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar
4Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust, Manchester, UK
Professor Rayaz A Malik; rayaz.a.malik at manchester.ac.uk


Pain reduction from injection lasted about 3 months
Ongoing monthly doses of oral 300,000 IU of vitamin D probably somewhat better
Active vitamin D may be better still – see below
See also VitaminDWiki: NEUROPATHY

See also VitaminDWiki: INJECTION

See also VitaminDWiki: LOADING DOSE

 Download the PDF from VitaminDWiki

Objective To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.

Methods A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.

Results 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).

Conclusions Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.

Trial registration number BIDE-12/2014.