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Chance of having more than one disease (multimorbidity) up 34 percent if low vitamin D – Sept 2015

Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.

Ann Med. 2015 Sep 4:1-8. [Epub ahead of print]
Meems LM1, de Borst MH, Postma DS, Vonk JM, Kremer HP, Schuttelaar MA, Rosmalen JG, Weersma RK, Wolffenbuttel BH, Scholtens S, Stolk RP, Kema IP, Navis G, Khan MA, van der Harst P, de Boer RA.

BACKGROUND:
The prevalence of multimorbidity (≥ 1 disease within an individual) is rapidly increasing. So far, studies on the relationship between vitamin D and morbidity are mainly focusing on effects on single disease domains only, while vitamin D biology is associated with several diseases throughout the human body.

METHODS:
We studied 8,726 participants from the LifeLines Cohort Study (a cross-sectional, population-based cohort study) and used the self-developed composite morbidity score to study the association between vitamin D levels and multimorbidity.

RESULTS:
Study participants (mean age 45 ± 13 years, 73% females) had a mean plasma vitamin D level of 59 ± 22 nmol/L. In participants aged between 50 and 60 years, 58% had ≥ 2 affected disease domains, while morbidity score increased with age (70-80 years: 82% morbidity score > 1; > 80 years: 89% morbidity score > 1).
Each incremental reduction by 1 standard deviation (SD) of vitamin D level was associated with an 8% higher morbidity score (full model OR 0.92, 95% CI 0.88-0.97, P = 0.001).
Participants with vitamin D levels < 25 nmol/L were at highest risk for increasing morbidity prevalence (versus > 80 nmol/L, OR 1.34, 95% CI 1.07-1.67, P = 0.01).

CONCLUSIONS:
Low levels of vitamin D are associated with higher prevalence of multimorbidity, especially in participants with vitamin D levels < 25 nmol/L. Collectively, our results favor a general, rather than an organ-specific, approach when assessing the impact of vitamin D deficiency.

PMID: 26340085

See also VitaminDWiki

Incidence of 22 health problems related to vitamin D have doubled in a decade
Diseases that may be related via low vitamin D which contains the following list

88+ Disease associations: Disease 1 ==> Disease 2 (both associated with low vitamin D

Statins ==> many diseases associated with low vitamin D update Jan 2012
Parkinson, Alzheimer, Stroke ==>Hip fracture
Parkinson's ==> Osteoporosis
Low Grip Strength ==> Osteoporosis
Immune System disease (CVID) ==> Osteoporosis
COPD ==> Osteoporosis
COPD ==> Bone Fracture 4.7 X
COPD ==> osteoporosis, cardio., skeletal muscle, anemia, metabolic synd.
HIV ==> Osteoporosis
Cancer - Prostate ==> Osteoporosis
Cancer - Prostate ==> Melanoma
Cancer - Gynecological ==> Atherosclerosis
Atopic Dermatitis ==> Osteopenia 1.8 X
Alopecia Areata spot baldness ==> 5X higher risk of Lupus, vitiligo, metabolic syndrome
Skin wrinkles ==> Fragile bones
Depression ==> Fragile bones
Depressed ==> Stroke 1.7X
Depression ==> Heart Disease 1.4X

Chance of having more than one disease (multimorbidity) up 34 percent if low vitamin D – Sept 2015

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- Migraines have low vitamin D, Migraines plus Restless Leg have far lower vitamin D (no surprise) – Dec 2021 Health Care is a Human Right in a most countries, but not the US Higher vitamin D associated with fewer health problems (37 ng vs 25 ng) – Brazil Nov 2017 Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin D

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