Cancers fought by repurposed drugs - aided by Vitamin D in many ways - Marik Aug 2025

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Cancer Care - Approach to the Use of Repurposed Drugs in Patients with Cancer

Independant Medical Alliance (had been FCCC)
Paul E. Marik, MD, FCCM, FCCP; Justus R. Hope, MD
 Download the PDF from VitaminDWiki
online PDF and supplementary materials

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Limited Therapy (D 7 ways)

Low carbohydrate, Low Glycemic diet. Broccoli sprouts 2x to 3x per week (Sulforaphane (VDR)), brewed green tea (< 4 cups/day)
Ivermectin (raises D) 0.2-0.4 mg/kg/day (0.3 mg/kg/day)
Doxycycline 50 mg daily taken together with 2 g oral Vitamin C (raises D) (consider cycling after 6 months)
Vitamin D 10 000 U daily and Vitamin K (raises D)2 100 ug (monitor 25-OH Vit D and PTH levels)
Curcumin (VDR) extract twice daily (high bioavailability). Daily dose of 2 -4 g titrate up to 8 g/day
Melatonin 20 mg at night (titrate up from 5 mg)
Propranolol 10-40 mg twice daily as tolerated
Resveratrol (VDR) 500 mg twice a day (high bioavailable)
Green tea extract (EGCG) twice a day (< 800 mg/day)

Aggressive therapy (D 9 ways)

Low Glycemic “ketogenic diet”
Ivermectin (raises D) 0.4-0.8 mg/kg/day (0.6 mg/kg/day). Increase the dose as tolerated up to 1 mg/kg/day if the response is poor.
Mebendazole 200 mg daily
Doxycycline 50 mg daily taken together with 2g oral Vitamin C (raises D) (consider cycling after 6 months)
Vitamin D 10 000 U daily and Vitamin K (raises D)2 100 ug (monitor 25-OH Vit d and PTH levels). Titrate to achieve a low normal PTH level (Coimbra Protocol)
Curcumin (VDR) extract twice daily (high bioavailability)
Metformin (VDR) 500 - 1000 mg twice daily
Green tea extract (EGCG) twice a day (< 800 mg/day)
Propranolol 10-40 mg twice daily as tolerated
Melatonin 20 mg at night (titrate up from 5 mg)
Resveratrol (VDR) 500 mg twice a day (high bioavailable)
Modified Citrus Pectin (Pectasol 14.4 g/day; 6 tablets three times a day)
Sulforaphane (VDR) (free stabilized Sulforaphane (VDR) extracted from broccoli seeds); dosage varies
Omega 3 (raises D) fatty acids 2-4 g/day
Atorvastatin 40-80 mg daily or simvastatin 40 mg daily (do not use long term or cause a precipitous reduction of LDL due to increased risk of dementia)
Propranolol 20-40 mg twice daily
Quercetin (VDR) 500-1000 mg twice daily

Colorectal Cancer (D 6 ways)

Ivermectin (raises D)
Curcumin (VDR)
Sulforaphane (VDR)
Metformin (VDR)
Atorvastatin/simvastatin
Modified Citrus Pectin
Propranolol
Resveratrol (VDR)
EGCG
Vitamin D
Mebendazole
Perioperative Cimetidine (400 mg BID for 1 year)

Breast Cancer (D 6 ways)

Mebendazole
Ivermectin (raises D)
Curcumin (VDR)
Propranolol 10-40 mg twice daily as tolerated
Doxycycline and Vitamin C (raises D)
Sulforaphane (VDR)
Modified citrus pectin
Vitamin D
Atorvastatin/simvastatin
Resveratrol (VDR)
EGCG

Prostate Cancer (D 8 ways)

Doxycycline (plus Vitamin C (raises D)
EGCG
Ivermectin (raises D)
Sulforaphane (VDR)
Curcumin (VDR)
Metformin (VDR)
Modified Citrus Pectin (Pectasol 14.4 g/day;6 tablets three times a day)
Vitamin D (aim for Vit D level of 100-150 ng/ml)
Mebendazole
Propranolol 10-40 mg twice daily as tolerated
Resveratrol (VDR)
Zinc (raises D) 15mg (dose < 20mg) for nonmetastatic disease. See caution below*
Quercetin (VDR) (synergizes with EGCG) - in poor responders, consider.
Atorvastatin 40-80mg day
Aspirin 325mg daily
Ketone supplements

Lung Cancer (small cell) (D 4 ways)

Curcumin (VDR)
EGCG
Metformin (VDR)
Mebendazole
Sulforaphane (VDR)
Atorvastatin/Simvastatin
Propanolol
Doxycycline and Vitamin C (raises D)
Ivermectin (raises D)
Vitamin D

Lung Cancer (NSCLC) (D 6 ways)

Mebendazole
Ivermectin (raises D)
Curcumin (VDR)
EGCG
Metformin (VDR)
Sulforaphane (VDR)
Atorvastatin/Simvastatin
Modified citrus pectin
Vitamin D
Doxycycline and Vitamin C (raises D)

Melanoma (D 5 ways)

Mebendazole
Ivermectin (raises D)
Doxycycline plus Vitamin C (raises D)
EGCG
Propranolol
Metformin (VDR)
Sulforaphane (VDR)
Modified citrus pectin
Vitamin D

Ovarian Cancer (D 7 ways)

Mebendazole
Curcumin (VDR)
Sulforaphane (VDR)
Metformin (VDR)
Ivermectin (raises D)
Atorvastatin/Simvastatin
Propranolol
Resveratrol (VDR)
Doxycycline plus Vitamin C (raises D)
Modified citrus pectin
Vitamin D

Endometrial Cancer (uterine cancer) (D 6 ways)

Metformin (VDR)
Curcumin (VDR)
Ivermectin (raises D)
Sulforaphane (VDR)
Mebendazole
EGCG
Resveratrol (VDR)
Atorvastatin
Propranolol
Modified citrus pectin
Vitamin D

Liver Cancer (D 6 ways)

Mebendazole
Ivermectin (raises D)
Curcumin (VDR)
Doxycycline plus Vitamin C (raises D)
Sulforaphane (VDR)
EGCG
Metformin (VDR)
Modified citrus pectin
Propranolol
Melatonin
Vitamin D

Head and Neck Squamous cancer (D 5 ways)

Doxycycline plus Vitamin C (raises D)
EGCG
Metformin (VDR)
Mebendazole
Ivermectin (raises D)
Curcumin (VDR)
Modified citrus pectin
Vitamin D

Esophageal Squamous Cell Carcinoma (D 6 ways)

Curcumin (VDR)
EGCG
Vitamin D
Azithromycin (1,500mg once weekly for 8 weeks)
Quercetin (VDR)
Modified citrus pectin
Ivermectin (raises D)
Mebendazole
Metformin (VDR)
Resveratrol (VDR)
Atorvastatin

Pancreatic cancer (D 6 ways)

Curcumin (VDR)
High dose Vitamin D3 (Coimbra protocol)
Doxycycline plus Vitamin C (raises D) 2g (PO)
Ivermectin (raises D) (start dose at 1 mg/kg and increase as tolerated)
Metformin (VDR)
Atorvastatin/Simvastatin
Propranolol
Modified citrus pectin
Mebendazole
Vitamin D
High dose IV Vitamin C (raises D) (50- 75g) together with standard chemotherapy (gemcitabine and capecitabine)
Hydroxychloroquine 200-400 mg day; max dose of 5 mg/kg/day to reduce retinopathy risk. Regular eye exams are recommended to detect early signs of retinal toxicity.

Gastric Cancer (D 5 ways)

Atorvastatin
Ivermectin (raises D)
Curcumin (VDR)
Metformin (VDR)
Modified citrus pectin
Resveratrol (VDR)
Vitamin D
Mebendazole

Glioblastoma (D 8 ways)

Curcumin (VDR)
Doxycycline plus Vitamin C (raises D)
Metformin (VDR)
Resveratrol (VDR)
Melatonin
Mebendazole
Sulforaphane (VDR)
Propranolol
Ivermectin (raises D) (See paragraph below for more)
Vitamin D
Atorvastatin/Simvastatin
Zinc (raises D) (30mg day)
EGCG

Repurposed drugs for patients with established stage 4 metastatic disease. (D 5 ways)

Doxycycline (up to 200 mg/day) plus Vitamin C (raises D)
Ivermectin (raises D)
Mebendazole
Curcumin (VDR)
Metformin (VDR)
Resveratrol (VDR)
EGCG
Atorvastatin/Simvastatin

Preventing cancer progression from carcinoma in situ (stage 0 cancer) (D 6 ways)

Doxycycline plus Vitamin C (raises D)
EGCG
Mebendazole
Resveratrol (VDR)
Ivermectin (raises D)
Metformin (VDR)
Sulforaphane (VDR)
Curcumin (VDR)
Propranolol
Modified citrus pectin

Repurposed drugs to treat Lymphoma (adjunctive treatment) (D 6 ways)

Atorvastatin 40-80 mg daily
Metformin (VDR) 500-1000 mg twice a day
Propranolol 10-40 mg twice a day, increase the dose as tolerated
Mebendazole 100 mg twice daily
Vitamin D 10 000 U daily and Vitamin K (raises D)2 100 ug (monitor 25-OH Vit d and PTH levels). Titrate to achieve a low normal PTH level (Coimbra Protocol)
Curcumin (VDR) (high bioavailable) 2-4 g/day
Green tea (EGCG) extract twice daily (< 800 mg/day)
Quercetin (VDR) 500 -1000 mg twice daily
Ivermectin (raises D) 0.4 mg/kg - 1 mg/kg daily

Repurposed drugs to treat Multiple Myeloma (adjunctive treatment) (D 4 ways)

Atorvastatin 40-80 mg daily
Metformin (VDR) 500-100 mg twice daily
Clarithromycin 500 mg twice daily in 28-day cycles (cycled with adjunctive therapy)
Celecoxib (Celebrex) 100 mg twice/day. Avoid in patients with established ischemic heart disease. Check for drug interactions
Mebendazole 10 0mg twice daily
Propranolol 10-40 mg twice a day, increase the dose as tolerated
Curcumin (VDR) (high bioavailable) 2-4 g/day
Green tea (EGCG) extract twice daily (< 800 mg/day)
Resveratrol (VDR) (high bioavailable) 500mg twice day
Ivermectin (raises D) 0.4 mg/kg - 1 mg/kg daily

Acute Myeloid Leukemia (AML) - Pediatric (no radiation and standard chemo) (D 7 ways)

Resveratrol (VDR)
Ivermectin (raises D)
Curcumin (VDR)
Doxycycline/Vitamin C (raises D) (oral)
Metformin (VDR)
EGCG
Omega 3 (raises D)
Sulforaphane (VDR)

Sarcomas (D 3 ways)

Late diagnosis
High drade and aggressiveness
Large tumor size
Metastasis at diagnosis
Tumor location
Incomplete surgical removal
Tumor heterogeneity
Resistance to conventional therapy
Propranolol (particularly for angiosarcomas)
EGCG
Curcumin (VDR)
Vitamin D
Mebendazole
High dose IV Vitamin C (raises D)

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