Vitamin D Deficiency after Anterior Cruciate Ligament Reconstruction Associates with Knee Osteoarthritis: A Retrospective Study
Nutrients. 2024 Sep 8;16(17):3029. doi: 10.3390/nu16173029.
Sonu Bae 1, Laura C Schmitt 1 2, Zachary Burnett 3, Eric M Milliron 3, Parker A Cavendish 3, Robert A Magnussen 1 3, Christopher C Kaeding 1 3, David C Flanigan 1 3, Tyler Barker 1 4
Background/objectives: The objective of this study was to test the hypothesis that vitamin D deficiency (i.e., serum 25-hydroxyvitamin D (25(OH)D) ≤ 20 ng/mL) associates with the increased occurrence and shortened time to a knee osteoarthritis (OA) diagnosis after anterior cruciate ligament reconstruction (ACLR).
Methods: This study consisted of a retrospective, case-control design. The inclusion criteria consisted of (1) patients (≥18 y) who underwent arthroscopic ACLR with (cases; n = 28) and without (controls; n = 56) a subsequent knee OA diagnosis (≥90 d from the date of ACLR) and (2) with a documented serum 25(OH)D concentration after ACLR (and before a knee OA diagnosis for the cases). Controls were matched (2:1) to cases based on sex, age at ACLR, date of ACLR, and body mass index. After matching, patients were separated into two groups: (1) vitamin D deficient (serum 25(OH)D ≤ 20 ng/mL) or (2) non-vitamin D deficient (serum 25(OH)D > 20 ng/mL). Data were extracted from the medical records.
Results: Thirty-one percent (n = 26) of patients included were vitamin D deficient. Fifty percent (n = 13) of the vitamin D deficient and twenty-six percent (n = 15) of the non-vitamin D deficient patients were subsequently diagnosed with knee OA (p = 0.03). Time from ACLR to a knee OA diagnosis was significantly (p = 0.02) decreased in the vitamin D deficient (OA-free interval, 95% confidence interval CI = 7.9 to 10.9 y) compared to the non-vitamin D deficient group (OA-free interval, 95% CI = 10.5 to 12.5 y).
Conclusions: Vitamin D deficiency after ACLR may serve as a prognostic biomarker for knee OA following ACLR.
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28+ VitaminDWiki pages with KNEE OSTEOARTHRITIS in title
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Items found: 28
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ACL Knee surgery increases risk of subsequent Knee Osteoarthritis by up to 2X (both low D) – Sept 2024 |
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19 Sep, 2024 |
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Knee osteoarthritis treated by Vitamin D - many studies |
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13 Dec, 2023 |
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Knee Osteoarthritis treated by vitamin D if use more than 2,000 IU daily or non-daily high dose – meta-analysis Aug 2023 |
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21 Aug, 2023 |
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I needed more than Vitamin D to treat my knee osteoarthritis |
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06 Nov, 2021 |
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Knee osteoarthritis helped by Low Level Laser Therapy |
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02 Nov, 2020 |
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Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020 |
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21 Oct, 2020 |
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Less Knee Osteoarthritis if take more Vitamin D – 8 MRI confirmations – Nov 2018 |
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10 Oct, 2018 |
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Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT July 2018 |
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10 Jul, 2018 |
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Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng) June 2017 |
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29 Jul, 2017 |
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Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015 |
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29 Jul, 2017 |
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Reduced knee osteoarthritis if consistently supplement with vitamin D for 2 years – April 2017 |
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29 Jul, 2017 |
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Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 |
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20 Jul, 2017 |
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Knee osteoarthritis not helped by Vitamin D (when you ignore vitamin D levels) – April 2017 |
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25 Apr, 2017 |
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Knee osteoarthritis strongly associated with low Boron – 2015 |
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24 Mar, 2017 |
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Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 |
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24 Dec, 2016 |
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Synovitis (knee osteoarthritis) associated with low vitamin D – Dec 2016 |
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21 Dec, 2016 |
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Hypothesis- Knee osteoarthritis is reduced by vitamin D increasing level of nitric oxide – Dec 2013 |
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06 Oct, 2016 |
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Good evidence for knee osteoarthritis and vitamin D, unsure of other OA – Review March 2013 |
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06 Oct, 2016 |
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Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 |
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08 Mar, 2016 |
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Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015 |
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03 Oct, 2015 |
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Will knee osteoarthritis be prevented with 1700 IU of vitamin D – proposed RCT |
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08 Aug, 2015 |
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Knee osteoarthritis more painful if low vitamin D, especially among obese – Jan 2015 |
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12 Apr, 2015 |
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Knee Osteoarthritis 3.2X more likely to get worse if low Vitamin D and high PTH – Dec 2014 |
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23 Feb, 2015 |
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Knee osteoarthritis 2.3 X more likely to get worse if low level of vitamin D – Dec 2014 |
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07 Oct, 2014 |
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Blacks had lower vitamin D and more quantifiable pain than whites with knee osteoarthritis – Nov 2012 |
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11 May, 2014 |
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Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 |
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10 Nov, 2012 |
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Knee osteoarthritis associated with low vitamin D for those under age 55 – Dec 2010 |
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10 Nov, 2012 |
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Knee Osteoarthritis pain cut in half by eating sesame seed powder for 2 months - Oct 2019 |
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No value for 'modification_date_major' |