Cystic fibrosis bronchial epithelial cells have impaired ability to activate Vitamin D.
Acta Paediatr. 2016 Feb 10. Doi: 10.1111/apa.13361. [Epub ahead of print]
Pincikova T1,2,3, Svedin E3, Domsgen E3, Flodström-Tullberg M3, Hjelte L1,2.
- 1 Stockholm CF Center, Karolinska University Hospital Huddinge, Stockholm, Sweden.
- 2 Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
- 3 Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
The vitamin D receptor system is widely expressed in the human body, including immune system cells and epithelial cells (1). The enzyme responsible for the second hydroxylation step in the production of active vitamin D, 1alpha-hydroxylase (Cyp27B), is not just expressed in the kidneys, as previously thought (2).
Primary lung epithelial cells have been shown to activate vitamin D (3). The focus of recent vitamin D research has been to test the effect of the active form of vitamin D in vitro (4-6) and this has led to increased knowledge about the role of active vitamin D in the immune system and in antimicrobial defence. The picture that has emerged from studies strongly suggests that active vitamin D has an important function in regulating inflammation and infection, including in cystic fibrosis (5-6).
PMID: 26865115 PDF is available in DeepDyve.com
Reference #3
Respiratory Epithelial Cells Convert Inactive Vitamin D to its Active Form - 2008
Download the PDF from VitaminDWiki
Respiratory epithelium Wikipedia
See also VitaminDWiki
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Cystic Fibrosis category page in VitaminDWiki follows:
(Note: Must click here to see attachements
- Cystic fibrosis (CF) is a genetic disorder that affects the lungs, pancreas, and other organs, leading to severe respiratory and digestive problems.
- 162,428 people are living with CF around the world.
- 105,352 (65%) have been diagnosed
- 57,076 individuals undiagnosed (Summary by Perplexity AI - March 2024)
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Summary of Associations
| Associated category | Associations |
|---|---|
Results
7 pages in both categories: Cystic Fibrosis + Intervention
3 pages in both categories: Cystic Fibrosis + Intervention - non daily
3 pages in both categories: Cystic Fibrosis + Vitamin D and Magnesium
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| Cystic Fibrosis is associated with low Magnesium, supplementation would probably help -review 2016 | 815 | Vitamin D and Magnesium, Cystic Fibrosis | 09 Sep, 2022 |
| Half of Cystic Fibrosis patients have low Magnesium levels – April 2022 | 1409 | Vitamin D and Magnesium, Cystic Fibrosis | 08 Sep, 2022 |
| MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015 | 20067 | Bone - Health, Breathing, Pregnancy, Diabetes, Depression, Vitamin D and Magnesium, Parkinson, Cystic Fibrosis, Hypertension, Stroke | 06 Nov, 2016 |
3 pages in both categories: Cystic Fibrosis + Top news
Page |
Hits
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Categories
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Major change |
|---|---|---|---|
| 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D | 21606 | Skin - Dark, Deficiency of Vitamin D, Cardiovascular, Kidney, Diabetes, Obesity, Cancer, Cystic Fibrosis, High Risk, Top news, Hypertension, Virus | 03 Nov, 2021 |
| Many Ashkenazi Jewish diseases associated with low vitamin D or poor Vit D genes | 6066 | Cancer - Colon, Cancer - Breast, Cancer - Pancreatic, Cystic Fibrosis, Genetics , Top news, Vitamin D in Europe | 20 Jan, 2020 |
| Death due to cystic fibrosis reduced about 4X due to 250000 IU of vitamin D – RCT June 2012 | 9292 | Cystic Fibrosis, Intervention, Top news | 17 Mar, 2015 |
6 pages in both categories: Cystic Fibrosis + Breathing
Page |
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Categories
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Major change |
|---|---|---|---|
| Nebulized glutathione treats various lung conditions - March 2025 | Breathing, Cystic Fibrosis | 02 Mar, 2025 | |
| Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022 | 2966 | Breathing, Immunity, Cystic Fibrosis, Inflammation, Virus | 19 Sep, 2022 |
| Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019 | 2183 | Breathing, Cystic Fibrosis | 26 Nov, 2019 |
| Vitamin D in respiratory diseases – Spring 2017 | 6578 | Breathing, Tuberculosis, Cystic Fibrosis | 09 Apr, 2017 |
| MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015 | 20067 | Bone - Health, Breathing, Pregnancy, Diabetes, Depression, Vitamin D and Magnesium, Parkinson, Cystic Fibrosis, Hypertension, Stroke | 06 Nov, 2016 |
| Vitamin D and the Lung – professional book 2012 | 4729 | Breathing, Tuberculosis, Books, videos on Vitamin D, Cystic Fibrosis | 11 Jan, 2013 |
3 pages in both categories: Cystic Fibrosis + Diabetes
Page |
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Major change |
|---|---|---|---|
| Water-soluble form of vitamins are needed for some health problems | 3 | Liver, Diabetes, Multiple Sclerosis, Obesity, Psoriasis, Tuberculosis, Rheumatoid Arthritis, Depression, Headache, Autism, Parkinson, Cystic Fibrosis, Gut, Stroke, AI | 03 Sep, 2024 |
| 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D | 21606 | Skin - Dark, Deficiency of Vitamin D, Cardiovascular, Kidney, Diabetes, Obesity, Cancer, Cystic Fibrosis, High Risk, Top news, Hypertension, Virus | 03 Nov, 2021 |
| MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015 | 20067 | Bone - Health, Breathing, Pregnancy, Diabetes, Depression, Vitamin D and Magnesium, Parkinson, Cystic Fibrosis, Hypertension, Stroke | 06 Nov, 2016 |
2 pages in both categories: Cystic Fibrosis + Depression
Page |
Hits
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Categories
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Major change |
|---|---|---|---|
| Water-soluble form of vitamins are needed for some health problems | 3 | Liver, Diabetes, Multiple Sclerosis, Obesity, Psoriasis, Tuberculosis, Rheumatoid Arthritis, Depression, Headache, Autism, Parkinson, Cystic Fibrosis, Gut, Stroke, AI | 03 Sep, 2024 |
| MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015 | 20067 | Bone - Health, Breathing, Pregnancy, Diabetes, Depression, Vitamin D and Magnesium, Parkinson, Cystic Fibrosis, Hypertension, Stroke | 06 Nov, 2016 |
2 pages in both categories: Cystic Fibrosis + Parkinson
Page |
Hits
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Categories
|
Major change |
|---|---|---|---|
| Water-soluble form of vitamins are needed for some health problems | 3 | Liver, Diabetes, Multiple Sclerosis, Obesity, Psoriasis, Tuberculosis, Rheumatoid Arthritis, Depression, Headache, Autism, Parkinson, Cystic Fibrosis, Gut, Stroke, AI | 03 Sep, 2024 |
| MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015 | 20067 | Bone - Health, Breathing, Pregnancy, Diabetes, Depression, Vitamin D and Magnesium, Parkinson, Cystic Fibrosis, Hypertension, Stroke | 06 Nov, 2016 |
2 pages in both categories: Cystic Fibrosis + Hypertension
Page |
Hits
|
Categories
|
Major change |
|---|---|---|---|
| 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D | 21606 | Skin - Dark, Deficiency of Vitamin D, Cardiovascular, Kidney, Diabetes, Obesity, Cancer, Cystic Fibrosis, High Risk, Top news, Hypertension, Virus | 03 Nov, 2021 |
| MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015 | 20067 | Bone - Health, Breathing, Pregnancy, Diabetes, Depression, Vitamin D and Magnesium, Parkinson, Cystic Fibrosis, Hypertension, Stroke | 06 Nov, 2016 |
2 pages in both categories: Cystic Fibrosis + Stroke
Page |
Hits
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Categories
|
Major change |
|---|---|---|---|
| Water-soluble form of vitamins are needed for some health problems | 3 | Liver, Diabetes, Multiple Sclerosis, Obesity, Psoriasis, Tuberculosis, Rheumatoid Arthritis, Depression, Headache, Autism, Parkinson, Cystic Fibrosis, Gut, Stroke, AI | 03 Sep, 2024 |
| MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015 | 20067 | Bone - Health, Breathing, Pregnancy, Diabetes, Depression, Vitamin D and Magnesium, Parkinson, Cystic Fibrosis, Hypertension, Stroke | 06 Nov, 2016 |
3 pages in both categories: Cystic Fibrosis + Genetics
2 pages in both categories: Cystic Fibrosis + Psoriasis
Page |
Hits
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Categories
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Major change |
|---|---|---|---|
| Water-soluble form of vitamins are needed for some health problems | 3 | Liver, Diabetes, Multiple Sclerosis, Obesity, Psoriasis, Tuberculosis, Rheumatoid Arthritis, Depression, Headache, Autism, Parkinson, Cystic Fibrosis, Gut, Stroke, AI | 03 Sep, 2024 |
| Might use Vitamin D for cystic fibrosis and topically on skin – June 2011 | 4397 | Dental, Psoriasis, Cystic Fibrosis | 20 Jun, 2011 |
2 pages in both categories: Cystic Fibrosis + Obesity
Page |
Hits
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Categories
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Major change |
|---|---|---|---|
| Water-soluble form of vitamins are needed for some health problems | 3 | Liver, Diabetes, Multiple Sclerosis, Obesity, Psoriasis, Tuberculosis, Rheumatoid Arthritis, Depression, Headache, Autism, Parkinson, Cystic Fibrosis, Gut, Stroke, AI | 03 Sep, 2024 |
| 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D | 21606 | Skin - Dark, Deficiency of Vitamin D, Cardiovascular, Kidney, Diabetes, Obesity, Cancer, Cystic Fibrosis, High Risk, Top news, Hypertension, Virus | 03 Nov, 2021 |
3 pages in both categories: Cystic Fibrosis + Tuberculosis
Page |
Hits
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Categories
|
Major change |
|---|---|---|---|
| Water-soluble form of vitamins are needed for some health problems | 3 | Liver, Diabetes, Multiple Sclerosis, Obesity, Psoriasis, Tuberculosis, Rheumatoid Arthritis, Depression, Headache, Autism, Parkinson, Cystic Fibrosis, Gut, Stroke, AI | 03 Sep, 2024 |
| Vitamin D in respiratory diseases – Spring 2017 | 6578 | Breathing, Tuberculosis, Cystic Fibrosis | 09 Apr, 2017 |
| Vitamin D and the Lung – professional book 2012 | 4729 | Breathing, Tuberculosis, Books, videos on Vitamin D, Cystic Fibrosis | 11 Jan, 2013 |
2 pages in both categories: Cystic Fibrosis + Gut
Page |
Hits
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Categories
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Major change |
|---|---|---|---|
| Water-soluble form of vitamins are needed for some health problems | 3 | Liver, Diabetes, Multiple Sclerosis, Obesity, Psoriasis, Tuberculosis, Rheumatoid Arthritis, Depression, Headache, Autism, Parkinson, Cystic Fibrosis, Gut, Stroke, AI | 03 Sep, 2024 |
| Vitamin D changed microbiota in gut and airway, might reduce cystic fibrosis – RCT Nov 2017 | 3210 | Cystic Fibrosis, Gut, Intervention, Intervention - non daily | 27 Nov, 2017 |
2 pages in both categories: Cystic Fibrosis + Vit D Binding Protein
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Categories
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Major change |
|---|---|---|---|
| Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022 | 845 | Cystic Fibrosis, Genetics , Vit D Binding Protein | 10 Feb, 2023 |
| Poor or no response to vitamin D was associated with poor genes (cystic fibrosis, 4 genes) Sept 2022 | 1142 | Cystic Fibrosis, Genetics , Vit D Binding Protein | 07 Sep, 2022 |
2 pages in both categories: Cystic Fibrosis + Virus
Page |
Hits
|
Categories
|
Major change |
|---|---|---|---|
| Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022 | 2966 | Breathing, Immunity, Cystic Fibrosis, Inflammation, Virus | 19 Sep, 2022 |
| 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D | 21606 | Skin - Dark, Deficiency of Vitamin D, Cardiovascular, Kidney, Diabetes, Obesity, Cancer, Cystic Fibrosis, High Risk, Top news, Hypertension, Virus | 03 Nov, 2021 |
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