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Some early Long-COVID symptoms persist for at least 3 years in US veterans – May 2024

Three-year outcomes of post-acute sequelae of COVID-19

Nature Medicine volume 30, pages1564–1573 (2024) https://doi.org/10.1038/s41591-024-02987-8
Miao Cai, Yan Xie, Eric J. Topol & Ziyad Al-Aly

Note: Might be different for people who are younger or older, or after later COVID variants


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in many organ systems. Risks of these sequelae have been characterized up to 2 years after infection, but longer-term follow-up is limited. Here we built a cohort of 135,161 people with SARS-CoV-2 infection and 5,206,835 controls from the US Department of Veterans Affairs who were followed for 3 years to estimate risks of death and PASC. Among non-hospitalized individuals, the increased risk of death was no longer present after the first year of infection, and risk of incident PASC declined over the 3 years but still contributed 9.6 (95% confidence interval (CI): 0.4–18.7) disability-adjusted life years (DALYs) per 1,000 persons in the third year. Among hospitalized individuals, risk of death declined but remained significantly elevated in the third year after infection (incidence rate ratio: 1.29 (95% CI: 1.19–1.40)). Risk of incident PASC declined over the 3 years, but substantial residual risk remained in the third year, leading to 90.0 (95% CI: 55.2–124.8) DALYs per 1,000 persons. Altogether, our findings show reduction of risks over time, but the burden of mortality and health loss remains in the third year among hospitalized individuals.
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VitaminDWiki - Long-COVID is now the biggest COVID concern - many studies

Attached files

ID Name Comment Uploaded Size Downloads
21388 DALYs hospitalized.webp admin 02 Jul, 2024 13.39 Kb 30
21386 Some initial long covid still persist for 3 years.webp admin 02 Jul, 2024 22.36 Kb 46
21385 Loong COVID.pdf admin 02 Jul, 2024 1.78 Mb 34