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Single 200,000 IU of vitamin D did not benefit the obese in various ways (not a surprise) – RCT Feb 2021

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Clinical Trial Diabetes Metab Syndr Obes . 2021 Feb 4;14:525-534. doi: 10.2147/DMSO.S285597. eCollection 2021.
Laine de Carvalho Guerra Pessoa Mamede 1, Rafaela Lira Formiga Cavalcanti de Lima 2, Alexandre Sérgio Silva 1, João Carlos Lima Rodrigues Pita 3, Nadjeanny Ingrid Galdino Gomes 1, Elisama Araújo de Sena 1, Rhayra Priscila Moraes Nobrega 2, João Otávio Scarano Alcântara 2, Julie Hanna Fontes de Souza 2, Glêbia Alexa Cardoso 3, José Luiz de Brito Alves 1, Maria da Conceição Rodrigues Gonçalves 1

Most were not above 30 ng at 1 month


Overview Obesity and Vitamin D contains the following summary


  • Normal weight     Obese     (50 ng = 125 nanomole)

Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has the following
Fast weight loss by Obese Adults: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
   If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
   * Vitamin D levels must be above 30ng/ml to help with weight loss
   * Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
   30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
   Note: Magnesium reduces weight loss by itself as well
   20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
  Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
   Vitamin D Receptor activator: 0-30% improved Vitamin D response
   Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
  His book does not mention Vitamin D nor Adenovirus

Items in both categories Obesity and Loading dose are listed here:

 Download the PDF from VitaminDWiki

Aim: The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D.

Methods: Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 intervention. Patients in the supplemented group received a single oral megadose of VD3 (VD3, n=14). Patients in placebo group received a single oral identical capsule without vitamin D (placebo, n = 15). Anthropometric and biochemical variables were assessed at baseline and after 4-weeks intervention.

Results: Anthropometric variables (waist circumference, waist-hip ratio, waist-height ratio and body mass index) were similar between groups (p > 0.05). VD3 supplementation increased the serum levels of 25-hydroxyvitamin D (p=0.000), malondialdehyde (p=0.021) and C-reactive protein (p=0.043) in overweight and obese women. Additionally, VD3 supplementation reduced the serum levels of aspartate aminotransferase (AST, p=0.035), alanine aminotransferase (ALT, p<0.0001) in overweight and obese women. Despite this, the serum levels of parathyroid hormone (PTH), fasting glucose (FG), and alpha-1- acid glycoprotein (A1GPA), total antioxidant capacity (TAC) were similar between groups.

Conclusion: In summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers.

Created by admin. Last Modification: Sunday June 27, 2021 23:01:57 GMT-0000 by admin. (Version 5)

Attached files

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15820 Megadose.jpg admin 27 Jun, 2021 22:55 18.86 Kb 310
15819 Oral megadose obese not help_compressed.pdf PDF 2021 admin 27 Jun, 2021 22:51 343.01 Kb 227