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Residents of a Nursing Home who choose monthly Vitamin D had 4X fewer COVID-19 deaths – Nov 2, 2020

Previous publication of the quasi-experiment in France was:
9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020

Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study

Nutrients 2020, 12(11), 3377; https://doi.org/10.3390/nu12113377
by Gaëlle Annweiler 1,2, Mathieu Corvaisier 3,4, Jennifer Gautier 3, Vincent Dubée 1,5,6, Erick Legrand 1,7, Guillaume Sacco 3,8 and Cédric Annweiler 1,3,8,9,10,* on behalf of the GERIA-COVID study group
Chart of data by VitaminDWiki

Review of Study by Grassroots Health
Background. The objective of this quasi-experimental study was to determine whether bolus vitamin D supplementation taken either regularly over the preceding year or after the diagnosis of COVID-19 was effective in improving survival among hospitalized frail elderly COVID-19 patients.

Methods. Seventy-seven patients consecutively hospitalized for COVID-19 in a geriatric unit were included. Intervention groups were participants regularly supplemented with vitamin D over the preceding year (Group 1), and those supplemented with vitamin D after COVID-19 diagnosis (Group 2). The comparator group involved participants having received no vitamin D supplements (Group 3). Outcomes were 14-day mortality and highest (worst) score on the ordinal scale for clinical improvement (OSCI) measured during COVID-19 acute phase. Potential confounders were age, gender, functional abilities, undernutrition, cancer, hypertension, cardiomyopathy, glycated hemoglobin, number of acute health issues at admission, hospital use of antibiotics, corticosteroids, and pharmacological treatments of respiratory disorders.

Results. The three groups (n = 77; mean ± SD, 88 ± 5years; 49% women) were similar at baseline (except for woman proportion, p = 0.02), as were the treatments used for COVID-19. In Group 1 (n = 29), 93.1% of COVID-19 participants survived at day 14, compared to 81.2% survivors in Group 2 (n = 16) (p = 0.33) and 68.7% survivors in Group 3 (n = 32) (p = 0.02). While considering Group 3 as reference (hazard ratio (HR) = 1), the fully-adjusted HR for 14-day mortality was HR = 0.07 (p = 0.017) for Group 1 and HR = 0.37 (p = 0.28) for Group 2. Group 1 had longer survival time than Group 3 (log-rank p = 0.015), although there was no difference between Groups 2 and 3 (log-rank p = 0.32). Group 1, but not Group 2 (p = 0.40), was associated with lower risk of OSCI score ≥5 compared to Group 3 (odds ratio = 0.08, p= 0.03).

Conclusions. Regular bolus vitamin D supplementation was associated with less severe COVID-19 and better survival in frail elderly.
 Download the PDF from VitaminDWiki

French National Academy recommended 100,000 IU of Vitamin D to elderly to fight COVID-19 - May 2020

COVID-19 treated by Vitamin D - studies, reports, videos in VitaminDWiki

As of Dec 1: 36 trials, 4 trial results, 3 meta-analyses, 32 observations, 15 recommendations, 35 associations, 80 speculations, 29 videos

Top Vitamin D and COVID-19 recent updates

Many clinical trials expect that high Vitamin D loading doses will fight COVID-19

Note: The highlighted author of this paper is the Principal Investigator for Clinical Trial #5

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Created by admin. Last Modification: Monday November 23, 2020 11:34:54 GMT-0000 by admin. (Version 14)

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14603 Annweiler GRH.jpg admin 23 Nov, 2020 11:28 127.37 Kb 77
14524 Quasi-Experimental Study.jpg admin 03 Nov, 2020 01:20 41.48 Kb 263
14523 Quasi-Experimental Study.pdf PDF 2020 admin 03 Nov, 2020 01:19 486.99 Kb 21
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