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COVID Ventilation 2X less likely if 200,000 IU of Vitamin D when enter hospital – May 2022


Effectiveness of Vitamin D Supplements among Patients Hospitalized for COVID-19: Results from a Monocentric Matched-Cohort Study

Healthcare 2022, 10(5), 956; https://doi.org/10.3390/healthcare10050956

  • 1 Infectious and Tropical Diseases Clinic, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy
  • 2 Unit of Respiratory Diseases, University Hospital Sassari (AOU), 07100 Sassari, Italy


Objectives: Our study aimed to evaluate the usefulness of Vitamin D3 (VitD3) among patients hospitalized for COVID-19. The primary endpoint was to evaluate the difference in survival rates between patients receiving and not VitD3. The secondary endpoints were to evaluate clinical outcomes, such as needing non-invasive ventilation (NIV), ICU transfer, and laboratory findings (inflammatory parameters).

Methods: We conducted a retrospective, monocentric matched-cohort study, including patients attending our ward for COVID-19. Patients were divided into two groups depending on VitD3 administration (Group A) or not (Group B ) among patients with low VitD levels (defined as blood levels < 30 ng/mL), which depended on physicians’ judgment. Our internal protocol provides VitD3 100,000 UI/daily for two days.

Findings: 58 patients were included in Group A, and 58 in Group B. Patients were matched for age, sex, comorbidities, COVID-19-related symptoms, PaO2/FiO2 ratio, blood exams, and medical treatments. Regarding the principal endpoint, there was a statistically significant difference between the two groups in survival rates [Group A vs. Group B = 3 vs. 11 (p = 0.042)]. When considering secondary endpoints, Group A patients were less likely to undergo NIV [Group A vs. Group B = 12 vs. 23 (p = 0.026)] and showed an improvement in almost all inflammatory parameters.

Conclusions: The link between VitD3 deficiency and the clinical course of COVID-19 during hospitalization suggests that VitD3 level is a useful prognostic marker. Considering the safety of supplementation and the low cost, VitD3 replacement should be considered among SARS-CoV-2 infected patients needing hospitalization
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VitaminDWiki - 20 studies in both categories Virus and Loading Dose

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70% of the RCT used at least a 100,000 IU during the first week (as of Oct 2020)

RCTs for COVID-19


Created by admin. Last Modification: Sunday May 22, 2022 19:31:46 GMT-0000 by admin. (Version 8)

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17641 COVID 100,000 IU.pdf PDF 2022 admin 22 May, 2022 15:03 252.29 Kb 75
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