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COVID-19 mortality reduced 4X (chart looks like 2X) by large, infrequent doses of Vitamin D in France – July 2021

Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study

J Steroid Biochem Mol Biol. 2021 Jul 28;105958. doi: 10.1016/j.jsbmb.2021.105958
Cédric Annweiler 1, Mélinda Beaudenon 2, Romain Simon 2, Mialy Guenet 2, Marie Otekpo 2, Thomas Célarier 3, Jennifer Gautier 2, GERIA-COVID study group
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VitaminDWiki

Note: This study combined all infrequent dosing into intervention data

  • 50,000IU per month, or
  • 80,000IU or 100,000IU or 200,000IU every 2-3 months

Note: The vitamin D levels did not rise very much for those getting this small amount of vitamin D
Note: 2-3 months dosing produces less than half the response as monthly dosing

Items in both categories Virus and Loading Dose are listed here:


Loading Dose of Vitamin D category has the following

204 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has 62 items
 
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading doses

TOP articles in Loading Dose of Vitamin D


Note: >70% of the RCT using Vitamin D to fight COVID-19 are using
at least 100,000 IU during the first week

RCTs for COVID-19

 Download the PDF from VitaminDWiki
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VitaminDWiki suspect that there is data error.
The above table shows that those supplementing had LOWER vitamin D levels

Background: The objective of this extension phase of the quasi-experimental GERIA-COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19.

Methods: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000IU per month, or 80,000IU or 100,000IU or 200,000IU every 2-3 months), or daily supplementation with 800IU. Comparator group involved those without vitamin D supplements (n = 28). Outcome was 3-month mortality. Covariables were age, sex, functional abilities, history of malignancies, cardiomyopathy, undernutrition, number of acute health issues, antibiotics use, systemic corticosteroids use, and 25(OH)D concentration.

Results: 76.1% (n = 51) of participants survived at 3 months in Intervention group, compared to only 53.6% (n = 15) in Comparator group (P = 0.03). The fully-adjusted hazard ratio for 3-month mortality was HR = 0.23[95%CI:0.09;0.58](P = 0.002) in Intervention group compared to Comparator group. Intervention group had also longer survival time (log-rank P = 0.008).

Conclusions: Vitamin D3 supplementation was associated with better 3-month survival in older COVID-19 patients.


Created by admin. Last Modification: Sunday August 1, 2021 15:20:06 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
16017 French table.jpg admin 01 Aug, 2021 51.20 Kb 358
16016 French.jpg admin 01 Aug, 2021 31.07 Kb 384
16015 50K per month helped_compressed.pdf admin 01 Aug, 2021 214.23 Kb 332