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COVID-19 mortality reduced 4X (chart looks like 2X) by large, infrequent doses of Vitamin D in France – July 2021

Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study

J Steroid Biochem Mol Biol. 2021 Jul 28;105958. doi: 10.1016/j.jsbmb.2021.105958
Cédric Annweiler 1, Mélinda Beaudenon 2, Romain Simon 2, Mialy Guenet 2, Marie Otekpo 2, Thomas Célarier 3, Jennifer Gautier 2, GERIA-COVID study group
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VitaminDWiki

Note: This study combined all infrequent dosing into intervention data

  • 50,000IU per month, or
  • 80,000IU or 100,000IU or 200,000IU every 2-3 months

Note: The vitamin D levels did not rise very much for those getting this small amount of vitamin D
Note: 2-3 months dosing produces less than half the response as monthly dosing

Items in both categories Virus and Loading Dose are listed here:


Loading Dose of Vitamin D category has the following

173 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Injection category listing has 60 items
 
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of adverse reactions
Many studies report on the benefits resulting from loading doses

The TOP articles in Loading Dose of Vitamin D are listed here:


Note: >70% of the RCT using Vitamin D to fight COVID-19 are using
at least 100,000 IU during the first week

RCTs for COVID-19

 Download the PDF from VitaminDWiki
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VitaminDWiki suspect that there is data error.
The above table shows that those supplementing had LOWER vitamin D levels

Background: The objective of this extension phase of the quasi-experimental GERIA-COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19.

Methods: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000IU per month, or 80,000IU or 100,000IU or 200,000IU every 2-3 months), or daily supplementation with 800IU. Comparator group involved those without vitamin D supplements (n = 28). Outcome was 3-month mortality. Covariables were age, sex, functional abilities, history of malignancies, cardiomyopathy, undernutrition, number of acute health issues, antibiotics use, systemic corticosteroids use, and 25(OH)D concentration.

Results: 76.1% (n = 51) of participants survived at 3 months in Intervention group, compared to only 53.6% (n = 15) in Comparator group (P = 0.03). The fully-adjusted hazard ratio for 3-month mortality was HR = 0.23[95%CI:0.09;0.58](P = 0.002) in Intervention group compared to Comparator group. Intervention group had also longer survival time (log-rank P = 0.008).

Conclusions: Vitamin D3 supplementation was associated with better 3-month survival in older COVID-19 patients.


Created by admin. Last Modification: Sunday August 1, 2021 15:20:06 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
16017 French table.jpg admin 01 Aug, 2021 13:50 51.20 Kb 69
16016 French.jpg admin 01 Aug, 2021 13:49 31.07 Kb 68
16015 50K per month helped_compressed.pdf PDF 2021 admin 01 Aug, 2021 13:40 214.23 Kb 27
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