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Pneumonia 2.6X more likely if low vitamin D – April 2013

Serum 25-hydroxyvitamin D3 and the risk of pneumonia in an ageing general population

J Epidemiol Community Health doi:10.1136/jech-2012-202027
Alex Aregbesola, alex.aregbesola at uef.fi
Sari Voutilainen,
Tarja Nurmi,
Jyrki K Virtanen,
Kimmo Ronkainen,
Tomi-Pekka Tuomainen
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, North Savo, Finland
Received 5 October 2012; Revised 15 February 2013; Accepted 21 March 2013; Published Online First 17 April 2013

Background Vitamin D has been suggested to have a role in infection defence and on the immune system. We therefore investigated the effect of serum 25-hydroxyvitamin D3 (25(OH)D3) on the risk of incident hospitalised pneumonia in an ageing general population in eastern Finland.

Methods The study population included 723 men and 698 women aged 53–73 years from the prospective population-based Kuopio Ischemic Heart Disease Risk Factor study who were free of pneumonia, other pulmonary diseases and cancer at baseline in 1998–2001. Incident pneumonia episodes leading to hospitalisation were collected by record linkage to the hospital discharge register. The serum vitamin D status was assayed as 25(OH)D3 concentration. Cox proportional hazards regression models were used to analyse the effect of serum 25(OH)D3 on the risk of incident pneumonia.

Results The mean (SD) serum 25(OH)D3 concentration of the study population was 43.5 (17.8) nmol/l. 73 subjects had at least one hospitalisation episode due to pneumonia during an average follow-up of 9.8 years.
After multivariable adjustments, the subjects in the lowest serum 25(OH)D3 tertile had a 2.6-fold (95% CI 1.4 to 5.0, p trend across tertiles=0.005) higher risk of developing pneumonia compared with the subjects in the highest tertile. This significant result remained even after adjustment for the determinants of serum 25-hydroxyvitamin D3.

Conclusions These data suggest an inverse effect of serum 25(OH)D3 concentration on the risk of incident pneumonia in the general ageing population.

See also VitaminDWiki

Graph shows a 40% chance of wheezing at age 80 if have less than 10 nanograms of vitamin D

Pneumonia review by Vitamin D Council May 2014

Pneumonia 2.6X more likely if low vitamin D – April 2013

9035 visitors, last modified 07 May, 2015,

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- Pneumonia and low vitamin D - many studies Any supplementation with vitamin D reduced chance of pneumonia by 50 percent – Oct 2013 Acute pneumonia in children 3X less likely if greater than 30 ng of vitamin D – Jan 2021 Pneumonia acquired in hospital – 3X more likely to die if low vitamin D – June 2015 Pneumonia is increasing (now 1 in 6 child deaths), more vitamin D studies needed – June 2018 Pneumonia in seniors was 2.5X more likely if low vitamin D – June 2014 ICU patients with pneumonia stay 7 days longer if low vitamin D - Dec 2011 Non-TB lung disease (NTM) 4X more likely if less than 10 ng of vitamin D – April 2013 A little extra vitamin D did not reduce chance of pneumonia – July 2013 Rickets in 80 percent of infants with severe pneumonia – Sept 2010

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