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Non-TB lung disease (NTM) 4X more likely if less than 10 ng of vitamin D – April 2013

Severe vitamin D deficiency is associated with nontuberculous mycobacterial lung disease: a case-control study

Respirology, Vol. 18 Issue 4, DOI: 10.1111/resp.12109
Kyeongman Jeon1,†,
Su-Young Kim1,†,
Byeong-Ho Jeong1,
Boksoon Chang1,
Sung Jae Shin2,
Won-Jung Koh1, wjkoh at skku.edu
1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
2 Department of Microbiology, Yonsei University College of Medicine, Seoul, Korea

Background and objective: Previous studies have found evidence of an association between tuberculosis and vitamin D deficiency (VDD). However, the association between VDD and infection caused by nontuberculous mycobacteria (NTM) has never been studied. This study evaluated the prevalence and severity of VDD in NTM lung disease, and attempted to identify predictive factors.

Methods: Age- and sex-matched case-control study was conducted to assess the prevalence and severity of VDD in patients with NTM lung disease.

Results: After adjusting for potential confounding factors, the adjusted mean serum level of 25-hydroxyvitamin D [25(OH)D] levels was lower in 104 patients with NTM lung disease (10.7 ng/mL, 95% confidence interval [CI] 4.5-16.8 ng/mL) than that of 312 controls (13.7 ng/mL, 95% CI 7.4-19.5 ng/mL) (P = 0.012). Although the prevalence of VDD defined as serum 25(OH)D level <20 ng/ml was not different, severe VDD defined as serum 25(OH)D level <10 ng/ml was more prevalent in patients (P < 0.001). In multivariate analysis, severe (but not mild) VDD was independently associated with NTM lung disease (adjusted OR 3.9, 95% CI 1.9-8.5, P < 0.001).

Conclusions: Patients with NTM lung disease have a high prevalence of severe VDD and VDD was independently associated with NTM lung disease. Further studies are needed to examine causality.

PDF is attached at the bottom of this page

Increasing Incidence of Nontuberculous Mycobacteria, Taiwan, 2000–2008 CDC

Associated disease incidence increased from 2.7 to 10.2 cases per 100,000 patients.

More prevelant in the elderly women: perhaps 17 cases per 100,000

Nontuberculous Mycobacterial Disease Prevalence and Risk Factors: A Changing Epidemiology 2009
highest in persons aged >50 years (15.5 cases per 100,000 persons).
PDF is attached at the bottom of this page

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
3958 NTM 2009.pdf PDF admin 28 May, 2014 12:06 247.33 Kb 1615
3957 non-tuberculous.pdf PDF 2013 admin 28 May, 2014 11:57 218.54 Kb 640
3956 NTM.jpg admin 28 May, 2014 11:57 48.40 Kb 2481
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