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People reported taking pills, pills were all gone, but occasionally bottles were not opened – Dec 2015


There are 2 titles for this page on VitaminDWiki

  • People reported taking pills, pills were all gone, but occasionally bottles were not opened – Dec 2015
  • Noncompliance (800 IU of vitamin D is not enough to feel a benefit) – Dec 2015

Seems like weekday afternoons are best

Note: Vitamin D compliance is not very important.
Far more important is to take enough vitamin D ON AVERAGE.
It is OK to take missed vitamin D all on a single day

See also VitaminDWiki

Drug holidays: the most frequent type of noncompliance with calcium plus vitamin D supplementation in persistent patients with osteoporosis.

Patient Prefer Adherence. 2015 Dec 16;9:1771-9. doi: 10.2147/PPA.S88630. eCollection 2015.
Touskova T1, Vytrisalova M1, Palicka V2, Hendrychova T1, Fuksa L1, Holcova R1, Konopacova J1, Kubena AA1.
1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
2 Osteocentre, Institute of Clinical Biochemistry and Diagnostics, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.

MEMS systems recorded when bottles were opened


Example of compliance (one person)


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Afternoon/evening takers had the best compliance


Of those who reported the most compliance
15% reported missing a pill occasionally,
bu actually - 40% failed to open the bottle occasionally

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All current recommendations include calcium and vitamin D (Ca-D) as an integrated part of osteoporosis treatment. The purpose of this pilot study was to analyze compliance with a fixed combination of Ca-D in women persistent with the treatment.

An observational study was carried out in three osteocenters in the Czech Republic. Women with osteoporosis ≥55 years of age concurrently treated with oral ibandronate were eligible. Compliance was evaluated in a period of 3 months by Medication Event Monitoring System (MEMS), tablet count, and self-report. Nonpersistence was defined as a MEMS-based gap in the use of Ca-D to be 30 days or more.

A total of 73 patients were monitored, of which 49 patients were analyzed (target population). Based on MEMS, mean overall compliance was 71%; good compliance (≥80%) was observed in 59% of the patients. As many as 71% of the patients took drug holidays (≥3 consecutive days without intake); overall compliance of these patients was 59% and was slightly lower on Fridays and weekends. Patients without drug holidays were fully compliant (did not omit individual doses). Compliance differed according to daily time at which the patients mostly used the Ca-D. Afternoon/evening takers showed a mean overall compliance of 82% while morning/night takers only 51% (P=0.049). Based on MEMS, tablet count, and self-report, compliance ≥75% was observed in 59%, 100%, and 87% of the patients, respectively. Outcomes obtained by the three methods were not associated with each other. Undesirable concurrent ingestion of Ca-D and ibandronate was present only twice.

Despite almost perfect self-reported and tablet count-based compliance, MEMS-based compliance was relatively poor. Consecutive supplementation-free days were common; more than two-thirds of the patients took at least one drug holiday. This pilot study showed drug holiday to be the most important type of noncompliance with Ca-D in those who are persistent with the treatment.

PMID: 26719680

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Attached files

ID Name Comment Uploaded Size Downloads
6291 Drug Holiday F6.jpg admin 01 Jan, 2016 15:23 55.76 Kb 894
6290 Drug Holiday F5 PM best.jpg admin 01 Jan, 2016 15:23 41.25 Kb 736
6289 Drug Holiday T2.jpg admin 01 Jan, 2016 15:22 75.74 Kb 765
6288 Drug Holiday F1.jpg admin 01 Jan, 2016 15:22 76.61 Kb 803
6287 MEMS.jpg admin 01 Jan, 2016 15:21 37.33 Kb 1402
6286 Drug holidays.pdf PDF 2015 admin 01 Jan, 2016 15:21 1.15 Mb 628
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