Effect of high dose vitamin D supplementation in combination with weight loss diet on Glucose homeostasis, insulin resistance and matrix metalloproteinases in obese subjects with vitamin D deficiency: a double blind placebo-controlled randomized clinical trial.
Appl Physiol Nutr Metab. 2019 Dec 24. doi: 10.1139/apnm-2018-0773
Overview Obesity and Vitamin D contains the following summary
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 153 trials for vitamin D intervention of obesity as of Sept 2020
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Obese lost 3X more weight by adding $10 of Vitamin D
- FACT: Those with darker skins were more likely to be obese Sept 2014
- OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
- and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
- Obesity category has
Fast weight loss by Obese: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
* Vitamin D levels must be above 30ng/ml to help with weight loss
* Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
Note: Magnesium reduces weight loss by itself as well
20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
Vitamin D Receptor activator: 0-30% improved Vitamin D response
Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
His book does not mention Vitamin D nor Adenovirus
Aliashrafi S1, Ebrahimi-Mameghani M2, Jafarabadi MA3, Lotfi-Dizaji L4, Vaghef-Mehrabany E5, Rafie-Arefhosseini S6.
- 1 Student research Committee, Tabriz University of Medical science, Tabriz, Iran (the Islamic Republic of) ; SA.NUT89 at yahoo.com.
- 2 Nutrition Research center, Tabriz university of medical science, Tabriz, Iran (the Islamic Republic of) ; ebrahimimamagani at tbzmed.ac.ir.
- 3 Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Tabriz, Iran (the Islamic Republic of) ; M.asghari862 at gmail.com.
- 4 Student Research Committee, Tabriz university of medical science, Tabriz, Iran (the Islamic Republic of) ; lidal70 at yahoo.com.
- 5 Student Research committee, Tabriz university of medical science;, Tabriz, Iran (the Islamic Republic of) ; elnaz.vaghef at gmail.com.
- 6 Faculty of nutrition and food science, Tabriz University of medical science, Tabriz, Iran (the Islamic Republic of) ; arefhosseinir at tbzmed.ac.ir.
As there is limited and inconsistent evidence in potential role of vitamin D on insulin resistance and matrix metalloproteinases, this study aimed to examine the effect of vitamin D supplementation on glucose homeostasis, insulin resistance and matrix metalloproteinases in obese subjects with vitamin D deficiency. A total of 44 participants with serum 25(OH)D level ≤ 50 nmol/L and body mass index (BMI) 30-40 kg/m2 were randomly allocated into receiving weight reduction diet with either 50000 IU vitamin D3 pearl (n = 22) or placebo (n = 22) once weekly for 12 weeks.
Primary outcomes were changes in fasting serum glucose (FSG), homeostasis model assessment insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and matrix metalloproteinases (MMPs).
Secondary outcomes were changes in weight, body mass index (BMI), 25(OH) D, calcium, phosphorous and Parathyroid hormone (PTH).
Sun exposure and dietary intakes were also assessed. Serum levels of 25(OH) D3 increased significantly with a simultaneous decrease in serum concentration of PTH in vitamin D group. Weight, BMI, FSG and MMP-9 decreased significantly in both groups; while there were found significant differences in changes in weight, serum 25(OH) D3, PTH and MMP-9 levels between the groups.
Within and between groups analysis revealed no significant differences in serum calcium, phosphorous, serum insulin, HOMA-IR, QUICKI and MMP-2 after intervention. Our results indicated that improvement in vitamin D status resulted in greater reductions in weight and MMP-9 during weight loss. These preliminary results are sufficient to warrant a bigger study group.Obese taking 50,000 IU of vitamin D weekly lost more weight (again) – RCT Dec 2019
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