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Vitamin D2 should not be used as a Vitamin supplement for any mammal – Oct 2006

The case against ergocalciferol (vitamin D2) as a vitamin supplement

The American Journal of Clinical Nutrition, Volume 84, Issue 4, 1 October 2006, Pages 694–697, https://doi.org/10.1093/ajcn/84.4.694
Lisa A Houghton Reinhold Vieth


All life on the planet has been getting Vitamin D3 naturally for over 500 million years.
   Before the use of skeletons
Vitamin D2 is avaiable in small amounts in only a few forms of mushrooms
  ~ verv very few animals have evolved a good way to use vitamin D2

Vitamin D3 instead of D2 category in VitaminDWiki starts with

Some of the 104 items

 Download the PDF from VitaminDWiki

Supplemental vitamin D is available in 2 distinct forms: ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3). Pharmacopoeias have officially regarded these 2 forms as equivalent and interchangeable, yet this presumption of equivalence is based on studies of rickets prevention in infants conducted 70 y ago. The emergence of 25-hydroxyvitamin D as a measure of vitamin D status provides an objective, quantitative measure of the biological response to vitamin D administration. As a result, vitamin D3 has proven to be the more potent form of vitamin D in all primate species, including humans. Despite an emerging body of evidence suggesting several plausible explanations for the greater bioefficacy of vitamin D3, the form of vitamin D used in major preparations of prescriptions in North America is vitamin D2. The case that vitamin D2 should no longer be considered equivalent to vitamin D3 is based on differences in their efficacy at raising serum 25-hydroxyvitamin D, diminished binding of vitamin D2 metabolites to vitamin D binding protein in plasma, and a nonphysiologic metabolism and shorter shelf life of vitamin D2.
Vitamin D2, or ergocalciferol, should not be regarded as a nutrient suitable for supplementation or fortification.

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