J Clin Endocrinol Metab. 2012 Feb 8.
Pilz S, Dobnig H, Tomaschitz A, Kienreich K, Meinitzer A, Friedl C, Wagner D, Piswanger-Sölkner C, März W, Fahrleitner-Pammer A.
Department of Internal Medicine (S.P., H.D., A.T., K.K., C.P.-S., A.F.-P.), Division of Endocrinology and Metabolism; Clinical Institute of Medical and Chemical Laboratory Diagnostics (A.M., W.M.); Division for Transplantation (C.F.), Department of Surgery; and Department of Internal Medicine (D.W.), Division of Nephrology, Medical University of Graz, 8036 Graz, Austria; Department of Epidemiology and Biostatistics and EMGO Institute for Health and Care Research (S.P.), VU University Medical Center, 1081 BT Amsterdam, The Netherlands; Synlab Academy (W.M.), Synlab services LLC, D-68165 Mannheim, Germany; and Mannheim Institute of Public Health (W.M.), Ruperto Carola University Heidelberg, Medical Faculty Mannheim, D-68167 Mannheim, Germany.
Context:Vitamin D deficiency contributes to skeletal diseases and is highly prevalent among institutionalized elderly patients.
Whether low 25-hydroxyvitamin D (25[OH]D) concentrations are an independent risk factor for mortality in these patients is, however, unclear.
Objective:We aimed to evaluate whether 25(OH)D concentrations are associated with mortality.
Design, Setting, and Participants:This is a prospective cohort study among elderly female patients (age >70 yr) recruited from 95 nursing homes in Austria.
Main Outcome Measures:We calculated Cox proportional hazard ratios (HR) for all-cause mortality according to 25(OH)D quartiles.
Results:We examined 961 study participants (age 83.7 ± 6.1 yr). Median 25(OH)D concentration was 17.5 (interquartile range 13.7-25.5) nmol/liter, and 93% of our cohort had 25(OH)D levels below 50 nmol/liter. During a mean follow-up time of 27 ± 8 months, 284 patients died. Compared with the fourth quartile (25[OH]D >25.5 nmol/liter), the age-adjusted HR (with 95% confidence interval) was 1.49 (1.07-2.10) in the first 25(OH)D quartile (25[OH]D <14.0 nmol/liter), and this association remained significant after multivariate adjustments (HR = 1.56; 95% confidence interval = 1.01-2.40).
Conclusions:This Austrian study suggests that the majority of institutionalized female patients are vitamin D deficient during winter and that there was an inverse association of 25(OH)D and mortality. These data underscore the urgent need for effective strategies for the prevention and treatment of vitamin D deficiency, in particular in the setting of nursing homes.
- Overview Seniors and Vitamin D
- Drugs which create a vitamin D deficiency
- Twice as likely to die of cardiovascular disease if low on vitamin D – July 2010
- Vit D deficiency best prediction of death in hospital
- All Cause Mortality big improvement from 15 to 27 ng - Heaney chart 2010 (file) chart below
CLICK HERE for an Vitamin D Workshop for Seniors which was held Aug 2011
CLICK HERE for the Vitamin D Deficiencies page - which has a more complete chart for all people
- Nursing home residents 2X more likely to die of some surgeries – perhaps lack vitamin D
- Dementia 19X more likely if low vitamin D – Jan 2012
- Elderly often trapped in vitamin D vicious circles especially in nursing homes
- Hospital stay 6 days longer for nursing home residents with low vitamin D – Oct 2011
- “Sunlight Officers” in some Australian senior facilities – Sept 2011
- Fraser Health in Canada is giving 20000 IU vitamin D weekly to reduce falls – Nov 2011
- Vitamin D Omega 3 and Exercise are being used in controlled trial to support healthy ageing – Feb 2012
Have to wait until 2017 to find out if 2,000 IU helps
- All items in Mortality and Vitamin D 56 items as of Feb 2012
- Low vitamin D increased death rate 2X in Finland – Aug 2011
- Dr. Grant on vitamin D and mortality in VitaminDWiki - following graph