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Vertebral fractures 9X more likely in HIV patients having low vitamin D – Dec 2017

Vitamin D Status and the Relationship with Bone Fragility Fractures in HIV-Infected Patients: A Case Control Study

Int. J. Mol. Sci. 2018, 19(1), 119; doi:10.3390/ijms19010119, Published: 2 January 2018
Chiara Iaria 2, Antonino Catalano 1, Antonino Lasco 1, Vincenzo Arcoraci 1, Alberto Lo Gullo 1, Alessandra Bitto 1, Francesco Squadrito 1 and Antonio Cascio 3
1 Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy
2 Infectious Diseases Unit-ARNAS Civico, Di Cristina, Benfratelli, 90127 Palermo, Italy
3 Department of Health Promotion Sciences and Mother and Child Care “G. D’Alessandro”, University of Palermo, 90127 Palermo, Italy

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HIV-infected patients show high risk of fracture. The aims of our study were to determine the prevalence of vertebral fractures (VFs) and their associations with vitamin D in HIV patients. 100 patients with HIV infection and 100 healthy age- and sex-matched controls were studied. Bone mineral density was measured by quantitative ultrasound at the non-dominant heel. Serum osteocalcin and C-terminal telopeptide of collagen type 1 served as bone turnover markers. Bone ultrasound measurements were significantly lower in patients compared with controls (Stiffness Index (SI): 80.58 ± 19.95% vs. 93.80 ± 7.10%, respectively, p < 0.001). VFs were found in 16 patients and in 2 controls. HIV patients with vertebral fractures showed lower stiffness index (SI) (70.75 ± 10.63 vs. 83.36 ± 16.19, respectively, p = 0.045) and lower vitamin D levels (16.20 ± 5.62 vs. 28.14 ± 11.94, respectively, p < 0.02).
The majority of VFs (87.5%) were observed in HIV-infected patients with vitamin D insufficiency, and regression analysis showed that vitamin D insufficiency was significantly associated with vertebral fractures (OR 9.15; 95% CI 0.18–0.52, p < 0.04). VFs and are a frequent occurrence in HIV-infected patients and may be associated with vitamin D insufficiency.

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9103 vertebral fractures HIV.pdf PDF 2017 admin 02 Jan, 2018 14:01 1.42 Mb 564