Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial.
Nutrients. 2017 Jan 4;9(1). pii: E30. doi: 10.3390/nu9010030.
- Non-pregnant women, 58% were on contraceptives, German winter
- . . .” users of hormonal contraceptives had higher baseline levels and a stronger increase in 25(OH)D levels . . .”
- “ . . age ≥18 to ≤45 years, body mass index (BMI) 17 to 30 kg/m2, good physical and mental health. . . “
- Note: Women need more than 800 IU if start at a lower level of vitamin D
- obese
- pregnant or recently pregnant
- not on contraceptives
- dark skin
- taking a variety of drugs
- in poor health (>100 diseases are associated with low vitamin D)
- elderly (gut, liver, and kidney do not process vitamin D as efficiently)
See also VitaminDWiki
Raising Vitamin D level to 20 nanograms rarely results in any benefits
40 nanograms has been proven many time to provide benefits
- Vitamin D helps women in many ways – review April 2015
- ALL of the top 10 health problems of women are associated with low vitamin D
- Needed more than 1600 IU of vitamin D during pregnancy – RCT May 2013
- Dark skin pregnancies 2.6 times more likely to have low vitamin D – March 2017
- 3,800 IU Vitamin D during pregnancy did not help much – RCT Jan 2017
- Vitamin D needed to get children to just 20 ng in winter 800 IU white skin, 1100 IU dark (Sweden) – RCT June 2017
Note: women weigh more than children, thus will need more than 800 IU - Winter youths need at least 1200 IU of vitamin D to maintain 20 nanograms – RCT 2016
The pills contained much more than Vitamin D
Perhaps the added vitamind increased the response
Women on contraceptives started with higher level and had bigger responses
Download the PDF from VitaminDWiki
Pilz S1, Hahn A2, Schön C3, Wilhelm M4, Obeid R5.
- 1 Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. stefan.pilz at chello.at.
- 2 Institute of Food Science and Human Nutrition, Leibniz University of Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany. hahn at nutrition.uni-hannover.de.
- 3 BioTeSys GmbH, Schelztorstrasse 54-56, 73728 Esslingen, Germany. c.schoen at biotesys.de.
- 4 Department of Mathematics, Natural and Economic Sciences, University of Applied Science Ulm, Albert-Einstein-Allee 55, 89081 Ulm, Germany. wilhelm at hs-ulm.de.
- 5 Aarhus Institute of Advanced Studies, University of Aarhus, Hoegh-Guldbergs Gade 6B, Building 1632, DK-8000 Aarhus, Denmark. rima.obeid at uks.eu.
The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25(OH)D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101). Primary outcome measure was serum 25(OH)D. 196 participants completed the trial. Increases in 25(OH)D (median with interquartile range) from baseline to study end were 13.2 (5.9 to 20.7) nmol/L in the 200 IU group, and 35.8 (18.2 to 52.8) nmol/L in the 800 IU group (p < 0.001 for the between group difference). At study end, levels of ≥50 nmol/L were present in 70.4% of the 200 IU group and in 99% of the 800 IU group. Participants on hormonal contraceptives had higher baseline levels and a stronger increase in 25(OH)D. In conclusion, daily supplementation of 800 IU vitamin D3 during wintertime in Germany is sufficient to achieve a 25(OH)D level of at least 50 nmol/L in almost all women of childbearing age, whereas 200 IU are insufficient.
PMID: 28054964 PMCID: PMC5295074 DOI: 10.3390/nu9010030