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Needed more than 1600 IU of vitamin D during pregnancy – RCT May 2013

Vitamin D requirement in pregnancy to prevent deficiency in neonates: a randomised trial.

Singapore Med J. 2013 May;54(5):285-288.
Shakiba M, Iranmanesh MR.
Paediatric Department, Shahid Sadoughi Medical University, Avicenna St, Yazd, Iran. shakiba at ssu.ac.ir.

Introduction: The exact amount of vitamin D required for pregnant women to adequately supply the foetus during pregnancy is still unclear. This randomised trial attempted to determine the optimal dose of vitamin D necessary during pregnancy in order to attain a vitamin D level > 20 ng/mL in neonates.

Methods: A total of 51 healthy, pregnant women in Yazd, Iran, were recruited in 2009. Of these, 34 were randomised to receive either

  • 50,000 IU (Group A ) or
  • 100,000 IU (Group B ) of vitamin D3

per month from the second trimester of pregnancy.
The remaining 17 pregnant women, who formed the third group

  • (Group C) and were found to have vitamin D deficiency, were initially treated with 200,000 IU of vitamin D3,
    following which the dose was adjusted to 50,000 IU per month.

25-hydroxyvitamin D (25[OH]D) in cord blood was measured by chemiluminescence immunoassay, and a serum 25(OH)D level < 20 ng/mL was defined as deficiency.

Results: All the pregnant women had a vitamin D level < 30 ng/mL at the beginning of the second trimester.
The neonates of 76% of women from Group A had sufficient levels of 25(OH)D.
All the neonates born to women in Groups B and C had 25(OH)D > 20 ng/mL.
No side effects were observed in our participants during the period of vitamin D supplementation.

Conclusion: A vitamin D3 dose > 50,000 IU/month is required during the second and third trimesters of pregnancy for vitamin D-deficient pregnant women in order for their neonates to achieve serum 25(OH)D levels > 20 ng/mL.
Supplementation with < 50,000 IU/month is insufficient to ensure a vitamin D level > 20 ng/mL in all neonates born to vitamin D-deficient pregnant women.

PMID: 23716156

Vitamin D levels needed

Vitamin D levels needed  at is.gd/neonate_vitD

PDF is attached at the bottom of this page

See also VitaminDWiki

Short url =http://is.gd/neonate_vitD

Attached files

ID Name Comment Uploaded Size Downloads
2533 Signapore neonate.pdf admin 31 May, 2013 338.44 Kb 1739