Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels - Results from a randomized trial.
Eur J Intern Med. 2013 Apr 5. pii: S0953-6205(13)00089-7. doi: 10.1016/j.ejim.2013.03.005.
Wamberg L, Kampmann U, Stødkilde-Jørgensen H, Rejnmark L, Pedersen SB, Richelsen B.
Dept. of Endocrinology and Internal Medicine MEA, Aarhus University Hospital, Aarhus, Denmark; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: louisewamberg at dadlnet.dk.
BACKGROUND: Low plasma 25-hydroxy-vitamin D (25OHD) is associated with obesity. Vitamin D (VD) may be implicated in obesity and its complications such as insulin resistance, hypertension, and low-grade inflammation. We investigated the effects of VD supplementation on fat distribution and on obesity complications in obese adults with low plasma levels of 25OHD.
METHODS: In a double-blind design 52 subjects aged 18 to 50 years with BMI>30kg/m2 and plasma 25OHD <50nmol/l were randomized to 26 weeks of treatment with 7000IU of VD daily or placebo. Body composition was assessed by DXA and subcutaneous (SAT) and visceral adipose tissue (VAT), intrahepatic (IHL) and intramyocellular lipids (IMCL) were evaluated by magnetic resonance imaging and magnetic resonance spectroscopy. Insulin resistance (HOMA-IR), blood pressure, plasma lipids, and circulating inflammatory markers were also investigated.
RESULTS: VD treatment increased mean plasma levels of 25OHD from 33nmol/l to 110nmol/l (P<0.0001) and decreased median parathyroid hormone levels from 5.3 to 4.5pmol/l (P<0.01) in the intervention group. Treatment did not change body fat, SAT, VAT, IHL, or IMCL compared with placebo. Neither did treatment affect HOMA, blood pressure, plasma lipids or any of several inflammatory markers investigated including hsCRP.
CONCLUSION: Increasing 25OHD levels by VD treatment for 26weeks have no effects on obesity complications in obese adults with low baseline plasma 25OHD.
Copyright © 2013. Published by Elsevier B.V.
7,000 IU raised serum levels to 44 ng in 26 weeks
Doubt that the serum levels had gotten to > 40 ng until the final weeks
Other studies do not show weight loss until > 50 ng for several months
Calcium would have also helped.
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