Lupus not helped by an unknown amount of Vitamin D – June 2022

---

Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)

PLoS One. 2022 Jun 29;17(6):e0270569. doi: 10.1371/journal.pone.0270569
Keigo Hayashi 1, Ken-Ei Sada 1 2, Yosuke Asano 1, Yu Katayama 1, Keiji Ohashi 1, Michiko Morishita 1, Yoshia Miyawaki 1, Haruki Watanabe 1, Takayuki Katsuyama 1, Mariko Narazaki 1, Yoshinori Matsumoto 1, Nobuyuki Yajima 3 4, Ryusuke Yoshimi 5, Yasuhiro Shimojima 6, Shigeru Ohno 7, Hiroshi Kajiyama 8, Kunihiro Ichinose 9, Shuzo Sato 10, Michio Fujiwara 11, Jun Wada 1

Why did they bother to write the article when they did not know how much Vitamin D was given?

Background: Although vitamin D concentration is reportedly associated with the pathogenesis and pathology of systemic lupus erythematosus (SLE), benefits of vitamin D supplementation in SLE patients have not been elucidated, to our knowledge. We investigated the clinical impacts of vitamin D supplementation in SLE.

Methods: A cross-sectional analysis was performed using data from a lupus registry of nationwide institutions. We evaluated vitamin D supplementation status associated with disease-related Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) as a parameter of long-term disease activity control.

Results: Of the enrolled 870 patients (mean age: 45 years, mean disease duration: 153 months), 426 (49%) received vitamin D supplementation. Patients with vitamin D supplementation were younger (43.2 vs 47.5 years, P < 0.0001), received higher doses of prednisolone (7.6 vs 6.8 mg/day, P = 0.002), and showed higher estimated glomerular filtration rates (79.3 vs 75.3 mL/min/1.73m2, P = 0.02) than those without supplementation. Disease-related SDI (0.73 ± 1.12 vs 0.73 ± 1.10, P = 0.75), total SDI, and SLE Disease Activity Index (SLEDAI) did not significantly differ between patients receiving and not receiving vitamin D supplementation. Even after excluding 136 patients who were highly recommended vitamin D supplementation (with age ≥ 75 years, history of bone fracture or avascular necrosis, denosumab use, and end-stage renal failure), disease-related SDI, total SDI, and SLEDAI did not significantly differ between the two groups.

Conclusions: Even with a possible Vitamin D deficiency and a high risk of bone fractures in SLE patients, only half of our cohort received its supplementation. The effect of vitamin D supplementation for disease activity control was not observed.
 Download the PDF from VitaminDWiki

---

VitaminDwiki - Lupus contains

78 items in LUPUS category

Some of the studies in VitaminDWiki

• Every aspect of Lupus is associated with low viramin D – Oct 2021
• It is time to routinely give vitamin D to Lupus patients – Dec 2016
• 93 pcnt of these Lupus patients supplemented with Vitamin D - Nov 2020
• Lupus patients are 5 X more likely to have low vitamin D – many meta-analyses
• Lupus fought by Vitamin D in all trials longer than 12 weeks - review Sept 2017

See also Autoimmune: 200 items    Rheumatoid Arthritis: 118 items

Autoimmune disease, mainly in 50 per 100,000 women, no cure, many parts of body Wikipedia

---

VitaminDWiki - 7 studies in both categories Lupus and Intervention

This list is automatically updated

---

VitaminDWiki 6 studies in both categories Lupus and Vitamin D Receptor

This list is automatically updated