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Lupus not helped by an unknown amount of Vitamin D – June 2022


Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)

PLoS One. 2022 Jun 29;17(6):e0270569. doi: 10.1371/journal.pone.0270569
Keigo Hayashi 1, Ken-Ei Sada 1 2, Yosuke Asano 1, Yu Katayama 1, Keiji Ohashi 1, Michiko Morishita 1, Yoshia Miyawaki 1, Haruki Watanabe 1, Takayuki Katsuyama 1, Mariko Narazaki 1, Yoshinori Matsumoto 1, Nobuyuki Yajima 3 4, Ryusuke Yoshimi 5, Yasuhiro Shimojima 6, Shigeru Ohno 7, Hiroshi Kajiyama 8, Kunihiro Ichinose 9, Shuzo Sato 10, Michio Fujiwara 11, Jun Wada 1

Why did they bother to write the article when they did not know how much Vitamin D was given?

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Background: Although vitamin D concentration is reportedly associated with the pathogenesis and pathology of systemic lupus erythematosus (SLE), benefits of vitamin D supplementation in SLE patients have not been elucidated, to our knowledge. We investigated the clinical impacts of vitamin D supplementation in SLE.

Methods: A cross-sectional analysis was performed using data from a lupus registry of nationwide institutions. We evaluated vitamin D supplementation status associated with disease-related Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) as a parameter of long-term disease activity control.

Results: Of the enrolled 870 patients (mean age: 45 years, mean disease duration: 153 months), 426 (49%) received vitamin D supplementation. Patients with vitamin D supplementation were younger (43.2 vs 47.5 years, P < 0.0001), received higher doses of prednisolone (7.6 vs 6.8 mg/day, P = 0.002), and showed higher estimated glomerular filtration rates (79.3 vs 75.3 mL/min/1.73m2, P = 0.02) than those without supplementation. Disease-related SDI (0.73 ± 1.12 vs 0.73 ± 1.10, P = 0.75), total SDI, and SLE Disease Activity Index (SLEDAI) did not significantly differ between patients receiving and not receiving vitamin D supplementation. Even after excluding 136 patients who were highly recommended vitamin D supplementation (with age ≥ 75 years, history of bone fracture or avascular necrosis, denosumab use, and end-stage renal failure), disease-related SDI, total SDI, and SLEDAI did not significantly differ between the two groups.

Conclusions: Even with a possible Vitamin D deficiency and a high risk of bone fractures in SLE patients, only half of our cohort received its supplementation. The effect of vitamin D supplementation for disease activity control was not observed.
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Created by admin. Last Modification: Friday July 1, 2022 12:44:35 GMT-0000 by admin. (Version 2)

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ID Name Comment Uploaded Size Downloads
18009 lupus unknown.jpg admin 30 Jun, 2022 14.53 Kb 138
18008 Lupus June 2022_CompressPdf.pdf admin 30 Jun, 2022 264.57 Kb 109